基于干细胞和内环境分析子宫内膜异位症的病因与预防  

The etiology and prevention of endometriosis in the perspective of stem cellsand internal environment

作　　者：袁鹏 刘朝阳 南燕 杨晓花 于帆 林换弟 谭宏伟 YUAN Peng;LIU Zhao Yang;NAN Yan;YANG Xiao Hua;YU Fan;LIN Huan Di;TAN Hong Wei(Northwest Women’s and Children’s Hospital,Xi’an 710061,Shaanxi Province,China;Shaanxi Provincial Maternity and Child Health Care Hospital,Xi’an 710061,Shaanxi Province,China)

机构地区：[1]西北妇女儿童医院,陕西西安710061 [2]陕西省妇幼保健院,陕西西安710061

出　　处：《中国妇幼卫生杂志》2023年第3期57-61,共5页Chinese Journal of Women and Children Health

摘　　要：子宫内膜异位症是对妇女健康及生育危害较大的一种常见病,其发病机制至今尚未完全明确。本研究对子宫内膜异位症的发病机制进行辩证分析,提出以干细胞理论为基础的“种子与环境”学说,整合子宫内膜异位症的各种发病机制,为病因预防子宫内膜异位症提供理论基础。本研究建议有痛经症状或有子宫内膜异位症家族史的青春期及育龄期女性,可以考虑使用含孕激素的避孕药或避孕药具;及时矫正生殖道畸形,解除原发性及继发性生殖道梗阻,减少经血逆流;减少涉及宫腔的手术操作,避免子宫内膜干细胞在手术创面的残留;保持健康的生活方式,加强孕期保健,减少早产及低体重儿的发生;保护环境,避免环境内分泌干扰物的摄入。Endometriosis is a common disease that is harmful to women’s health and fertility,and its pathogenesis has not yet been fully elucidated.The“seeds and environment”theory integrates the various pathogenesis of endometriosis and provides a solid theoretical basis for the prevention of endometriosis.Targeted primary preventive measures are recommended:Women with dysmenorrhea or a family history of endometriosis may consider using contraceptives containing progesterone during adolescence and childbearing age;Timely correction of genital malformation and relieving primary and secondary genital tract obstruction to reduce menstrual blood reflux;Reduce surgical operations in uterine cavity to avoid the residue of endometrial stem cells on the surgical wound;Maintain a healthy lifestyle and improve perinatal health care to reduce premature birth and low birth weight;Protect the environment and avoid intake of environmental endocrine disruptor.

关 键 词：子宫内膜异位症 子宫内膜干细胞 机体内环境 病因预防 环境内分泌干扰物 

分 类 号：R711.71[医药卫生—妇产科学]