晚期糖基化终末产物促进骨关节炎的机制  

Promotion mechanism of advanced glycation end products on osteoarthritis

作　　者：苏童 徐进 SU Tong;XU Jin(Shandong Provincial Hospital Affiliated to Shangdong First Medical University,Shandong,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院,济南市250021 [2]山东第一医科大学(山东省医学科学院)研究生部

出　　处：《河北医药》2023年第17期2679-2684,共6页Hebei Medical Journal

基　　金：山东省自然科学基金资助项目(编号:ZR2020MH111)。

摘　　要：骨关节炎(osteoarthritis,OA)是最常见的关节疾病。晚期糖基化终末产物(advanced glycation end products,AGEs)被认为是OA的重要介质或危险因素。当蛋白质或脂质暴露于过量的葡萄糖时会形成AGEs;又因为AGEs的形成是不可逆的,所以AGEs会在体内积累。过多的AGEs会引起体内电荷发生变化,还会通过形成交联对生物力学特性产生不利影响;AGEs会对软骨细胞、滑膜细胞造成多方面的影响,如引起线粒体的损伤和细胞外基质(extracellular matrix,ECM)改变。AGEs引起的炎性反应建立了AGEs和OA之间的联系。因此,寻找AGEs-OA的炎症通路有关的机制,并靶向炎症通路可能是治疗AGEs-OA的一种有前途的策略。目前与AGEs-OA炎症有关的机制包括AMPK通路的抑制、自噬水平的降低、NF-κB通路激活和GLUT1的上调等。本文探讨与AGEs-OA炎症相关的发病机制以及为AGEs-OA治疗提供新的作用靶点。Osteoarthritis(OA)is the most common joint disease.Advanced glycation end products(AGEs)are considered as important mediators or risk factors for OA.AGEs are formed when proteins or lipids are exposed to excess glucoses.The formation of AGEs is irreversible,and they are accumulated and excessive cause changes in body charge and adversely affect biomechanical properties through the formation of crosslinks.AGEs can affect chondrocytes and synovial cells in various ways,such as causing damage to mitochondria and changes in the extracellular matrix(ECM).Recent studies have shown that AGEs-induced inflammatory response establishes a link between AGEs and OA.Therefore,identifying mechanisms related to the inflammatory pathway of AGEs-induced OA and targeting the inflammatory pathway may be a promising strategy to treat AGEs-induced OA.Currently,the inhibition of adenosine monophosphate-activated protein kinase(AMPK)pathway,reduction of autophagy,activation of nuclear factorκB(NF-κB)metabolism,and upregulation of glucose transporter 1(GLUT1)are linked with the inflammatory response in AGEs-induced OA.This review provides an overview of the pathogenesis associated with AGEs-induced inflammation in OA and novel therapeutic targets.

关 键 词：骨关节炎 晚期糖基化终末产物 炎症 机制 治疗 

分 类 号：R684.3[医药卫生—骨科学]