FGF21在慢性肾脏疾病中的调控及潜在生物学作用  

Regulation and potential biological role of Fibroblast Growth Factor 21 in chronic kidney disease

作　　者：纪明雪 王振[2] JI Mingxue;WANG Zhen(Jiamusi University,Jiamusi,Heilongjiang 154007,China;Department of Nephrology,the First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154002,China)

机构地区：[1]佳木斯大学,黑龙江佳木斯154007 [2]佳木斯大学附属第一医院肾内科,黑龙江佳木斯154002

出　　处：《医药前沿》2023年第19期23-25,31,共4页Journal of Frontiers of Medicine

摘　　要：慢性肾脏病(CKD)是一种肾功能进行性损害的不可治愈的进行性疾病,可加速心血管疾病的进展,增加感染风险,并导致贫血、骨病等相关并发症。CKD在很大程度上是可以预防和治疗的,提高CKD的早期诊断水平,加强对疾病发生发展机制的研究,创造新的干预措施尤为重要。成纤维细胞生长因子21(FGF21)属于内分泌FGF亚家族成员之一,在能量平衡和脂肪代谢的调节中发挥重要作用。FGF21需要依赖β-Klotho蛋白与FGF受体(FGFR)特异性结合,激活FGF21信号通路发挥生物学功能。FGF21被认为是在生理和病理条件下广泛调节许多细胞功能的重要调节因子。尽管FGF21的代谢作用已被广泛研究,但其在肾脏的潜在生物学作用尚未被广泛研究。本文结合目前的研究,对FGF21的生物学特性、调控及生物学功能进行综述,并简要讨论其与慢性肾脏病的潜在关系。Chronic kidney disease(CKD)is an incurable progressive disease with the progressive impairment of kidney function,which can accelerate the progression of cardiovascular disease,increase the risk of infection,and lead to related complications such as anemia and bone disease.CKD is to a great extent preventable and treatable,and it is particularly important to improve the early diagnosis,strengthen the research underlying the mechanism of disease occurrence and development,and innovate new intervention measures.Fibroblast growth factor 21(FGF21)belongs to one of members of endocrine FGF subfamily with evolutionarily conserved functions and performs a vital role in the regulation of energy balance and adipose metabolism.FGF21 needs to rely onβ-Klotho protein to specifically bind to FGF receptor(FGFR),which activates the FGF21 signaling exerting the biological function.FGF21 is deemed as an important regulatory factor extensively modulating many cellular functions under physiologic and pathologic conditions.Although the metabolic effect of FGF21 has been extensively studied,its potential biological role in the kidney has not been generally investigated.In this review,we summarize the biological characteristics,regulation and biological function of FGF21 based on the current studies,and briefly discuss the potential relationship with chronic kidney disease.

关 键 词：FGF21 慢性肾脏病 生物学作用 糖尿病肾病 综述 

分 类 号：R692[医药卫生—泌尿科学]