补肾活血接骨汤对桡骨远端骨折患者术后骨折愈合、骨密度及骨代谢指标的影响  

Effect of Bushen Huoxue Jiegu Decoction on Postoperative Fracture Healing,Bone Mineral Density and Bone Metabolism Indexes in Patients with Distal Radius Fractures

作　　者：熊侃 易宏伟 谢峰 XIONG Kan;YI Hongwei;XIE Feng(Wuhan Jiangxia District Hospital of Traditional Chinese Medicine,Wuhan,Hubei,China 430200)

机构地区：[1]湖北省武汉市江夏区中医医院,湖北武汉430200

出　　处：《中国药业》2023年第17期108-111,共4页China Pharmaceuticals

基　　金：湖北省卫生和计划生育委员会科研立项项目[WJ2021XB015]。

摘　　要：目的探讨补肾活血接骨汤对桡骨远端骨折(DRF)患者术后骨折愈合、骨密度及骨代谢指标的影响。方法选取医院2019年7月至2022年6月收治的DRF患者96例,按随机数字表法分为观察组和对照组,各48例。两组患者均行经肱桡肌腱入路内固定术;观察组患者加用补肾活血接骨汤,治疗2个月。结果观察组患者的止痛时间、消肿时间、骨折愈合时间均显著短于对照组(P<0.05),术后6个月腕关节功能评分显著低于对照组(P<0.05);观察组患者术后的断端边缘、骨痂边缘、骨痂密度及骨痂量评分均显著高于对照组(P<0.05),血清总Ⅰ型胶原氨基端延长肽、骨钙素水平及骨密度均显著高于对照组(P<0.05),血清抗酒石酸酸性磷酸酶5b、β-胶原特殊序列水平均显著低于对照组(P<0.05);观察组和对照组术后不良反应发生率相当(4.17%比0,P>0.05)。结论补肾活血接骨汤可有效改善DRF术后患者的骨密度及骨代谢,加速骨折愈合,促进术后康复,且安全性良好。Objective To investigate the effect of Bushen Huoxue Jiegu Decoction on postoperative fracture healing,bone mineral density,and bone metabolism indexes in patients with distal radius fracture(DRF).Methods A total of 96 patients with DRF admitted to the hospital from July 2019 to June 2022 were selected and divided into the observation group and the control group by the random number table method,with 48 cases in each group.The patients in the two groups underwent internal fixation through the brachioradialis tendon approach,on this basis,the patients in the observation group were treated with Bushen Huoxue Jiegu Decoction.Both groups were treated for two months.Results The pain relief time,swelling reduction time,and fracture healing time in the observation group were significantly shorter than those in the control group(P<0.05),and the score of wrist joint function in the observation group was significantly lower than that in the control group at six months after operation(P<0.05).The scores of postoperative fracture edge,callus edge,callus density,and callus quantity in the observation group were significantly higher than those in the control group(P<0.05),the serum levels of total typeⅠcollagen amino terminal lengthening peptide(tPINP),osteocalcin(BGP),and bone mineral density in the observation group were significantly higher than those in the control group(P<0.05),while the serum levels of tartrate-resistant acid phosphatase 5b(TRACP-5b)andβ-cross laps in the observation group were significantly lower than those in the control group(P<0.05).The incidence of postoperative adverse reactions in the observation group was comparable to that in the control group(4.17%vs.0,P>0.05).Conclusion Bushen Huoxue Jiegu Decoction can effectively improve bone mineral density and bone metabolism in patients after DRF surgery,promote fracture healing and postoperative recovery,and it has good safety.

关 键 词：补肾活血接骨汤 桡骨远端骨折 术后恢复 骨折愈合 骨密度 骨代谢 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]