全视网膜激光光凝联合一次康柏西普眼内注射治疗糖尿病视网膜病变的临床疗效分析  

Clinical Efficacy of Total Retinal Laser Photocoagulation Combined with One Intracocular Injection of Compaplexil in the Treatment of Diabetic Retinopathy

作　　者：张加荣 周茹[2] 傅同圣 蔡玮 杨书琴 ZHANG Jiarong;ZHOU Ru;FU Tongsheng;CAI Wei;YANG Shuqin(Department of Ophthalmology,Yangzhong Mingchen Ophthalmology Hospital,Zhenjiang,Jiangsu Province,212200 China;Department of Ophthalmology,Yangzhong People's Hospital,Zhenjiang,Jiangsu Province,212200 China)

机构地区：[1]扬中明辰眼科医院眼科,江苏镇江212200 [2]扬中市人民医院眼科,江苏镇江212200

出　　处：《糖尿病新世界》2023年第15期25-29,共5页Diabetes New World Magazine

摘　　要：目的 探讨全视网膜激光光凝前联合一次康柏西普眼内注射治疗糖尿病视网膜病变患者的临床疗效。方法 选取2021年12月—2022年5月在扬中明辰眼科医院眼科进行全视网膜激光光凝治疗的糖尿病性视网膜病变患者50名(50眼),随机分为观察组(25名25眼)和对照组(25名25眼),观察组采用玻璃体腔注射康柏西普1周后进行全视网膜激光光凝,对照组直接进行全视网膜激光光凝,治疗后1个月及6个月使用OCT进行黄斑区视网膜厚度检查,治疗后6个月使用眼底血管荧光造影进行视网膜无灌注区、新生血管范围、荧光渗漏区域面积测算。结果 治疗后1个月及6个月,观察组患者的视力、黄斑区视网膜厚度均优于对照组,差异有统计学意义(P<0.05)。治疗后6个月时,两组视网膜无灌注区面积、视网膜新生血管区面积、视网膜荧光渗漏面积均较术前减小,且观察组明显优于对照组,差异有统计学意义(P<0.05)。结论 增殖期糖尿病视网膜病变患者在全视网膜激光光凝前进行一次康柏西普治疗,可以更好地提高患者术后视力,减轻术后黄斑水肿,改善视网膜无灌注区、新生血管及荧光渗漏,减少术后并发症。Objective To investigate the clinical effect of laser photocoagulation combined with one intracocular injection of Compaplexil in the treatment of diabetic retinopathy.Methods Fifty patients with diabetic retinopathy(50 eyes) who underwent total retinal laser photocoagulation treatment in the department of ophthalmology of Yangzhong Mingchen Ophthalmology Hospital from December 2021 to May 2022 were randomly divided into observation group(25 eyes) and control group(25 eyes).The observation group received total retinal laser photocoagulation after intraocular injection of Compaplexil for 1 week,while the control group received direct total retinal laser photocoagulation.Macular retinal thickness was examined by OCT at 1 and 6 months after treatment.At 6 months after treatment,fundus angiography was used to calculate the area of retina non-perfusion area,the scope of new blood vessels and the area of fluorescence leakage area.Results The visual acuity and macular retinal thickness of patients in the observation group were better than those in the control group at 1 and 6 months after treatment,and the difference was statistically significant(P<0.05).At 6 months after treatment,the area of retinal non perfusion area,retinal neovascularization area,and retinal fluorescence leakage area in the two groups decreased compared to before surgery,and the observation group was significantly better than the control group,and the difference was statistically significant(P<0.05).Conclusion In patients with proliferative diabetic retinopathy,one treatment of Compaplexil before total retinal laser photocoagulation can better improve postoperative visual acuity of patients,reduce postoperative macular edema,improve retinal non-perfusion area,neovascularization and fluorescence leakage,reduce postoperative complications.

关 键 词：糖尿病性视网膜病变 康柏西普 全视网膜激光光凝 光学相干断层扫描 眼底血管荧光造影 

分 类 号：R587.1[医药卫生—内分泌]