持续皮下胰岛素注射治疗老年2型糖尿病的效果研究  

Study on the Effect of Continuous Subcutaneous Insulin Injection in the Treatment of Type 2 Diabetes Mellitus in Elderly People

作　　者：陈敏 CHEN Min(Department of Internal Medicine,Tengzhou Workers'Hospital,Tengzhou,Shandong Province,277599 China)

机构地区：[1]滕州市工人医院内科,山东滕州277599

出　　处：《糖尿病新世界》2023年第15期103-106,共4页Diabetes New World Magazine

摘　　要：目的 探讨对老年2型糖尿病患者采用胰岛素持续皮下注射治疗后获得临床效果。方法 选取2020年2月—2022年4月滕州市工人医院收治的74例老年2型糖尿病患者为研究对象,以投掷硬币法分为两组,每组37例。施以生物合成人胰岛素多次皮下注射治疗的设为参照组,施以胰岛素连续腹部皮下注射治疗的设为研究组。对比两组老年2型糖尿病患者的氧化应激指标水平、胰岛细胞功能以及血糖水平、血糖日平均绝对差、血糖日平均波动速度。结果 治疗前,两组超氧化物歧化酶(superoxide dismutas,SOD)水平、丙二醛(malondialdehyde,MDA)水平比较,差异无统计学意义(P>0.05);治疗后,研究组SOD水平高于参照组,MDA水平低于参照组,差异有统计学意义(P<0.05)。治疗前,两组胰岛素抵抗指数(insulin resistance index,HOMA-IR)、胰岛β细胞功能指数(islet β cell function index,HOMA)、空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial blood glucose,2 hPG)水平比较,差异无统计学意义(P>0.05);治疗后,研究组HOMA-β高于参照组,HOMA、FPG、2 hPG水平低于参照组,差异有统计学意义(P<0.05)。研究组血糖日平均绝对差、血糖日平均波动速度优于参照组,差异有统计学意义(P<0.05)。结论 临床对老年2型糖尿病患者合理给予胰岛素持续皮下注射治疗,可快速控制患者的血糖波动,调节胰岛素功能,减轻氧化应激反应。Objective To explore the clinical effects obtained after the use of continuous subcutaneous insulin injection for the treatment of elderly type 2 diabetes mellitus patients.Methods A total of 74 elderly patients with type 2 diabetes treated in Tengzhou Workers' Hospital from February 2020 to April 2022 were selected as the study objects.They were divided into two groups by coin throwing method,with 37 cases in each group.The control group was given multiple subcutaneous injections of biosynthetic human insulin,and the study group was given continuous subcutaneous injections of insulin.The oxidative stress index level,islet cell function,blood glucose level,daily mean absolute difference of blood glucose and daily mean fluctuation rate of blood glucose were compared between the two groups of elderly patients with type 2 diabetes.Results Before treatment,there was no statistically significant difference in the level of superoxide dismutas(SOD) and malondialdehyde(MDA) between the two groups(P>0.05).After treatment,SOD level in the study group was higher than that in the control group,MDA level was lower than that in the group,and the difference was statistically significant(P<0.05).Before treatment,two groups of insulin resistance index(HOMA-IR) and pancreatic islets β cell function index(HOMA-β),fasting plasma glucose(FPG),and 2-hour postprandial blood glucose(2 hPG) levels were compared,and the difference was not statistically significant(P>0.05).After treatment,HOMA-β levels in the study group was higher than that in the control group,and HOMA,FPG and 2 hPG levels were lower than those in the control group,and the differences were statistically significant(P<0.05).The daily average absolute difference and daily average fluctuation rate of blood glucose in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion In clinical practice,continuous subcutaneous injection of insulin reasonably given to elderly patients with type 2 diabetes can

关 键 词：持续皮下胰岛素注射 老年2型糖尿病 胰岛细胞功能 血糖水平 

分 类 号：R4[医药卫生—临床医学]