瑞马唑仑复合瑞芬太尼用于无痛胃肠镜检查的应用研究  

Application of Remimazolam Combined with Remifentanil in Painless Gastroenteroscopy

作　　者：王香[1] 吴伟强[1] 韩超[1] WANG Xiang;WU Weiqiang;HAN Chao(Department of Anesthesiology,Yixing Hospital Affiliated to Jiangsu University,Yixing,Jiangsu Province,214200)

机构地区：[1]江苏大学附属宜兴医院麻醉科,江苏宜兴214200

出　　处：《中外医疗》2023年第20期94-97,共4页China & Foreign Medical Treatment

基　　金：无锡市科学技术协会课题(KX-22-C185)。

摘　　要：目的 观察将瑞马唑仑复合瑞芬太尼应用于无痛胃肠镜检查中的效果。方法 随机选取2021年9月—2022年5月在江苏大学附属宜兴医院门诊行无痛胃肠镜检查的患者100例作为研究对象,随机分为两组,即瑞马唑仑组(R组)和丙泊酚(P组),每组50例。对全部患者应用丙泊酚+瑞芬太尼。R组应用瑞马唑仑,30 s后静脉注射丙泊酚,术中根据体动情况追加瑞马唑仑;P组应用瑞芬太尼+丙泊酚,术中根据情况追加丙泊酚。对比两组生命体征、起效时间、苏醒时间、离室时间、Ramsay评分、不良反应发生情况。结果 T1、T2、T3时R组MAP均高于P组,T1、T2时R组HR高于P组,但T3时R组HR低于P组,差异有统计学意义(P<0.05)。两组起效时间、苏醒时间比较,差异无统计学意义(P>0.05);R组离室时间短于P组,差异有统计学意义(t=2.168,P=0.032);R组Ramsay评分(3.87±0.51)分明显高于P组(2.16±0.23)分,差异有统计学意义(t=21.612,P<0.001)。R组不良反应发生率明显低于P组,差异有统计学意义(P<0.05)。结论 瑞马唑仑复合瑞芬太尼用于无痛胃肠镜检查时血流动力学更平稳,呼吸抑制很少,离室也更快,能达到门诊需要的理想麻醉效果。Objective To observe the effect of remazolam combined with Remifentanil in painless gastroenteroscopy.Methods A total of 100 patients who underwent painless gastroenteroscopy in the outpatient department of Yixing Hospital Affiliated to Jiangsu University from September 2021 to May 2022 were randomly selected as the study objects and randomly divided into two groups,namely remazolam group(group R) and propofol group(group P),with 50 cases in each group.All patients were treated with propofol + remifentanil.Group R was treated with remazolam,propofol was injected intravenously after 30 s,and remazolam was added according to the movement conditions during the operation.Group P received remifentanil + propofol,and propofol was added according to the situation.The vital signs,onset time,recovery time,exit time,Ramsay score and the occurrence of adverse reactions were compared between the two groups.Results MAP in group R was higher than that in group P at T1,T2 and T3,HR in group R was higher than that in group P at T1 and T2,but HR in group R was lower than that in group P at T3,the difference was statistically significant(P<0.05).There was no statistically significant difference in onset time and recovery time between the two groups(P>0.05);the absence time of R group was shorter than that of P group,the difference was statistically significant(t=2.168,P=0.032);ramsay score in group R(3.87±0.51) points was significantly higher than that in group P(2.16±0.23) points,and the difference was statistically significant(t=21.612,P<0.001).The incidence of adverse reactions in group R was significantly lower than that in group P,and the difference was statistically significant(P<0.05).Conclusion Remimazolam combined with Remifentanil for painless gastroenteroscopy has more stable hemodynamics,less respiratory depression,faster exit from the chamber,and can achieve the ideal anesthetic effect required by the clinic.

关 键 词：瑞马唑仑 瑞芬太尼 丙泊酚 无痛胃肠镜检查 

分 类 号：R971[医药卫生—药品]