巴曲酶联合地塞米松治疗对突发性耳聋患者不良反应及效果的影响  

Effect of Batroxobin Combined with Dexamethasone on Adverse Reactions and Effects in Patients with Sudden Deafness

作　　者：林清花 蔡艳绯[1] 罗高青[1] LIN Qinghua;CAI Yanfei;LUO Gaoqing(Department of Otorhinolaryngology,Fujian Provincial Government Hospital,Fuzhou,Fujian Province,350000 China)

机构地区：[1]福建省级机关医院耳鼻咽喉科,福建福州350000

出　　处：《中外医疗》2023年第21期120-124,共5页China & Foreign Medical Treatment

摘　　要：目的 探讨突发性耳聋在地塞米松给药基础上取巴曲酶联用对不良反应及效果产生的影响。方法 随机选取2020年1月—2023年1月福建省级机关医院收治的突发性耳聋患者80例作为研究对象,按照随机数表法分为两组,每组40例。对照组采用地塞米松治疗,观察组在对照组基础上加用巴曲酶治疗。对比两组总有效率、症状缓解时间、凝血功能、血液流变学指标、听力水平、不良反应情况。结果 观察组总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(χ^(2)=4.507,P<0.05)。观察组呕吐持续时间、耳鸣持续时间、听力恢复时间、眩晕持续时间均短于对照组,差异有统计学意义(t=10.284、8.149、6.879、4.113,P<0.05)。治疗后观察组凝血功能、血液流变学指标均优于对照组,差异有统计学意义(P<0.05)。治疗后观察组高频、低频听力阈值均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 突发性耳聋在地塞米松给药基础上,取巴曲酶联用,可提高总有效率,缩短症状缓解时间,改善凝血功能及血液流变学,改善听力状况,且具一定安全性。Objective To explore the effect of combined administration of batroxobin and dexamethasone on the adverse reactions and effects of sudden deafness.Methods A total of 80 patients with sudden deafness admitted to provincial organ hospitals in Fujian Province from January 2020 to January 2023 were randomly selected as the study objects and divided into two groups,according to the random number table,with 40 cases in each group.The control group was treated with dexamethasone,and the observation group was treated with batroxase.The total effective rate,symptom remission time,coagulation function,hemorheology index,hearing level and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.50%,higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.507,P<0.05).The duration of vomiting,tinnitus,hearing recovery and vertigo in the observation group were shorter than those in the control group,and the differences were statistically significant(t=10.284,8.149,6.879,4.113,P<0.05).After treatment,the coagulation function and hemorheology indexes of the observation groups were better than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the high-frequency and low-frequency hearing thresholds in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of dexamethasone administration,batroxase combined with sudden deafness can increase the total effective rate,shorten the time of symptom relief,improve coagulation function and hemodynamics,improve hearing status,and have a certain safety.

关 键 词：突发性耳聋 地塞米松 巴曲酶 凝血功能 效果 不良反应 

分 类 号：R5[医药卫生—内科学]