长期糖皮质激素药物对哮喘患儿生长发育的影响  

Effect of long-term glucocorticoids on growth and development of children with asthma

作　　者：张征[1] Zhang Zheng(Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院,河南南南阳473000

出　　处：《辽宁医学杂志》2023年第3期56-58,共3页Medical Journal of Liaoning

摘　　要：目的 探讨长期糖皮质激素药物对哮喘患儿生长发育的影响。方法 选取2018年8月-2019年8月我院收治的60例哮喘患儿,按入院顺序分为对照组(n=30)和观察组(n=30)。对照组基础治疗,观察组使用糖皮质激素长期治疗。观察比较两组症状评分,身高、体重,血清Ca^(2+)、P^(3+)、骨钙素(BGP)及胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平。结果 治疗1年、2年后观察组评分高于对照组(P<0.05)。随访1年及2年,两组身高、体重无统计学意义(P>0.05)。两组治疗前、治疗1及2年后血清Ca^(2+)、P^(3+)、BGP、IGF-1、IGFBP-3水平差异均无统计学意义(P>0.05)。结论 长期使用糖皮质激素可改善哮喘患儿症状,对其生长发育影响不明显。Objective To investigate the effect of long-term glucocorticoid on the growth and development of children with asthma.Methods 60 asthmatic children admitted to our hospital from August 2018 to August 2019 were selected and divided into the control group(n=30)and the observation group(n=30)according to the order of admission.The control group received basic treatment,while the observation group received long-term treatment with glucocorticoid.The symptom scores,height,weight,serum Ca^(2+),P^(3+),ostecalcin(BCP),insulin-ke growh factor-1(IGF-1)and insulin-like growh factor binding protein-3(IGFBP-3)were observed and compared between the two groups.Results The scores in the observation group were higher than those in the control group after 1 and 2 years of treatment(P<0.05):There was no significant difference in height and weight between the two groups after 1 and 2 years of follow-up(P>0.05).There was no significant difference in serum Ca^(2+),P^(3+),BGP,IGF-1,IGFBP-3 levels between the two groups before and after treatment for 1 and 2 years(P>0.05).Conclusion Long term use of glucocorticoid can effectively improve the symptoms of children with asthma,and has no significant impact on the growth and development of children.

关 键 词：糖皮质激素 哮喘 生长发育 

分 类 号：R725.6[医药卫生—儿科]