针对儿童年龄依赖指标建立连续参考区间的必要性及方法学进展  

Necessity and methodological progress on the establishment of continuous reference intervals for pediatric age-dependent indicators

作　　者：严若华 彭晓霞[1] 彭亚光[1] 李昆 倪鑫[2] Yan Ruohua;Peng Xiaoxia;Peng Yaguang;Li Kun;Ni Xin(Center for Clinical Epidemiology and Evidence-based Medicine,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Beijing Key Laboratory for Pediatric Diseases of Otolaryngology,Head and Neck Surgery,Beijing Children′s Hospital,Capital Medical University,National Center for Children Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院临床流行病学与循证医学中心,北京100045 [2]国家儿童医学中心,首都医科大学附属北京儿童医院耳鼻咽喉头颈外科,儿童耳鼻咽喉头颈外科疾病北京市重点实验室,北京100045

出　　处：《中华检验医学杂志》2023年第8期872-878,共7页Chinese Journal of Laboratory Medicine

基　　金：北京市科技新星计划(Z211100002121053);国家卫生计生委医政医管局委托项目(2017374);国家自然科学基金(72174128)。

摘　　要：准确、适用的参考区间可为疾病诊断、疗效评价及健康监测提供重要依据。许多临床检验指标存在年龄依赖趋势,对此类指标的结果判读应考虑年龄因素的影响。然而,划分年龄亚组的参考区间在实际应用中存在局限性,而连续参考区间不仅可以为精准判读检验结果提供参考,还可以为动态监测其变化趋势提供基线。该文基于本研究团队在儿童参考区间方面进行的研究,介绍建立连续参考区间的不同算法及其适用条件与实现步骤,为我国连续参考区间的建立提供方法学参考与实现途径。Accurate and applicable reference intervals can provide important information for disease diagnosis,efficacy evaluation,and health monitoring.Age-dependent trends exist for many clinical laboratory indicators,and the interpretation of such indicators should consider the effect of age carefully.However,age-specific reference intervals have certain limitations in clinical application.Continuous reference intervals can not only help accurate interpretation of laboratory test results,but also provide a baseline value for dynamic monitoring of their changing trends.Based on the researches on pediatric reference intervals from our team,this paper introduces different algorithms for establishing continuous reference intervals,and their applicable conditions and implementation steps.The aim of this paper is to provide methodological guidance for the establishment of continuous reference intervals,so as to improve the quality of laboratory reports and the accuracy of clinical diagnosis in China.

关 键 词：儿童 参考区间 非参数法 半参数法 

分 类 号：R179[医药卫生—妇幼卫生保健]