他汀类药物抗肿瘤作用的表观与非表观遗传调节及临床研究进展  

The epigenetic and non-epigenetic regulation of statins on its anti-tumor effect and its clinical research progress

作　　者：王媛茹 李学军[2] WANG Yuan-ru;LI Xue-jun(School of Pharmacy,Shihezi University,Shihezi 832000,China;School of Basic Medical Science,Peking University,Beijing 100191,China)

机构地区：[1]石河子大学药学院,新疆石河子832000 [2]北京大学医学部基础医学院,北京100191

出　　处：《药学学报》2023年第8期2146-2154,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81673453,82073878,81874318)。

摘　　要：他汀类药物是一类羟甲基戊二酰辅酶A还原酶(hydroxymethylglutaryl coenzyme A,HMG-CoA)抑制剂,是目前临床广泛应用的降血脂药物,对心血管系统疾病的防治尤为重要。近年来,国内外多项研究认为他汀类药物在肿瘤防治中有独特的作用,并得到广泛关注。在表观遗传调节机制方面,他汀类药物主要通过DNA甲基化、组蛋白修饰和非编码RNA的调节影响肿瘤的进程。此外,他汀类药物也能通过促进肿瘤细胞自噬、调节肿瘤细胞周期、促进肿瘤细胞凋亡等信号通路实现其抗肿瘤作用。因此,对他汀类药物的研究为发现新型抗肿瘤治疗方式提供思路。本文就他汀类药物在防治常见肿瘤方面的作用进行综述,包括其通过表观遗传调节抑制肿瘤发生发展的作用机制以及其他相关机制,及其抗肿瘤的临床研究现状。Statins are a class of hydroxymethylglutaryl-CoA reductase inhibitors(HMG-CoA reductase inhibitors),which are widely used to reduce blood lipid in clinic,and are especially important for the prevention and treatment of cardiovascular diseases.In recent years,many studies at home and abroad believe that statins have a unique role in tumor prevention and treatment,and have been widely concerned.In terms of epigenetic regulation mechanism,statins mainly affect the progress of tumor through DNA methylation,histone modification and miRNA regulation.In addition,statins can also achieve their anti-tumor effects by promoting tumor cell autophagy,regulating tumor cell cycle,and promoting tumor cell apoptosis and other signaling pathways.Therefore,the research on statins provides ideas for the discovery of new anti-tumor treatments.In this paper,the role of statins in the prevention and treatment of common tumors is reviewed,including its mechanism of inhibiting the occurrence and development of tumors through epigenetic regulation and other related mechanisms,as well as its clinical research status.

关 键 词：他汀类药物 肿瘤 表观遗传 临床研究 甲羟戊酸途径 

分 类 号：R966[医药卫生—药理学]