黄芪有效成分防治器官纤维化的研究进展  

Research progress of effective components of Astragalus on prevention and treatment of organ fibrosis

作　　者：李世粉 杨若轩 孙健 梁海海[1] LI Shi-fen;YANG Ruo-xuan;SUN Jian;LIANG Hai-hai(College of Pharmacy,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学药学院,黑龙江哈尔滨150081

出　　处：《药学学报》2023年第8期2168-2179,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(32171127);黑龙江省杰出青年基金资助项目(JQ2022H001).

摘　　要：黄芪首载于《神农本草经》,为豆科草本植物膜荚黄芪或蒙古黄芪的干燥根。其有效成分皂苷类(astragalus membranaceus saponins,AMS)、多糖类(astragalus polysaccharides,APS)、黄酮类(astragalus flavonoids,AFS)等具有抗肿瘤、降血糖、调节脂质代谢、抗氧化和保护心血管等功效。纤维化可发生于多种器官,特别是肺、肝、心、肾等重要器官,主要病理过程为肌成纤维细胞异常增多及细胞外基质(extracellularmatrix,ECM)过度沉积,导致瘢痕组织形成,最终诱发器官功能丧失及器官衰竭,严重威胁人类健康和生命。近年来,研究表明黄芪在抗器官纤维化方面有较好的疗效。本文就黄芪有效成分在防治肺、肝、心、肾等重要器官纤维化的研究进展进行综述。Astragalus,which was first documented in Shennong Bencao Jing,is the dried root of Astragalus membranaceus(Fisch.)Bge.or Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao.The active ingredients astragalus membranaceus saponins(AMS),astragalus polysaccharides(APS)and astragalus flavonoids(AFS)have pharmacological effects such as anti-tumor properties,lowering blood sugar,regulating lipid metabolism,cardiovascular protection,anti-oxidation,bone protection,anti-fibrosis,etc.Fibrosis affects almost all organs,particularly vital organs such as the lungs,liver,heart and kidneys.The primary pathological changes of fibrosis involve abnormal increase of myofibroblasts and excessive deposition of extracellular matrix(ECM)components,which lead to the formation of scar tissue,ultimately resulting in fibrosis and even functional loss or failure of organs,which seriously threatens human health and life.Recent,studies have shown that Astragalus membranaceus has a good therapetuic effect on organ fibrosis.This article reviews the current advances of Astragalus in the prevention and treatment of fibrosis of lungs,liver,heart,kidneys and other important organs.

关 键 词：黄芪 黄芪多糖 黄芪甲苷 黄芪黄酮 器官纤维化 细胞外基质 

分 类 号：R966[医药卫生—药理学]