光敏剂递送系统及肿瘤光动力治疗的研究进展  

Recent progress in delivery systems for photosensitizers and anti-cancer photodynamic therapy

作　　者：佟勤丽 陈梦婷 林洪铮 程群仙 陆伟[1,2] 徐灵 TONG Qin-li;CHEN Meng-ting;LIN Hong-zheng;CHENG Qun-xian;LU Wei;XU Ling(Minhang Hospital,Fudan University,Shanghai 201199,China;School of Pharmacy,Key Laboratory of Smart Drug Delivery,Ministry of Education&State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 201203,China)

机构地区：[1]复旦大学附属闵行医院,上海201199 [2]复旦大学药学院,智能化递药教育部重点实验室,聚合物分子工程国家重点实验室,上海201203

出　　处：《药学学报》2023年第8期2320-2333,共14页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金(81991493,81673018);上海市卫生健康委员会人才计划项目(2022XD045)。

摘　　要：光动力治疗(photodynamic therapy,PDT)是一种新型肿瘤治疗手段,用于皮肤癌、膀胱癌和前列腺癌等多种肿瘤的临床治疗。大多数光敏剂具有疏水性,存在生物利用度低和肿瘤靶向性差等缺点。纳米递送系统可增加光敏剂的溶解性,促进其在肿瘤部位的富集,可通过制备联合其他抗肿瘤药物的多功能递送系统,增强肿瘤协同治疗效果。需要提出的是,光敏剂递送系统在解决光敏剂溶解性差和肿瘤靶向性不足等问题的同时,还需要改善光敏剂在体内的药动学性质,促进其在肿瘤部位快速富集和体内快速清除,降低光敏剂的光毒性。本文总结了近年PDT在肿瘤治疗中的临床应用、光敏剂的发展、光敏剂递送系统以及和其他治疗方法的联合应用,旨在为新型光敏剂递送系统的设计及其在肿瘤PDT的临床应用提供参考。Photodynamic therapy(PDT)is a new modality for cancer therapy,which has been used in the clinical treatment for various tumors,such as skin cancer,bladder cancer and prostate cancer.Most photosensitizers have the disadvantages of hydrophobic,low bioavailability and the limited tumor targeting ability.The nanoscale delivery systems can improve the solubility of photosensitizers and enhance their accumulation at the tumor sites.The multifunctional nano-delivery systems are prepared in combination with other anti-tumor drugs to enhance the anti-tumor effect.In addition to addressing the issues of poor solubility and the insufficient tumor targeting ability,the nanoscale delivery systems need to improve the pharmacokinetic properties of photosensitizers,facilitating their rapid accumulation at the tumor sites and quick elimination in vivo,and reducing the skin phototoxicity.This review summarizes the recent clinical application of PDT of cancer,the development of photosensitizers,the delivery systems for photosensitizers and the combinatorial application with other therapeutic methods.The goal is to present an understanding of knowledge on the design of new types of photosensitizers and its clinical application in PDT of cancer.

关 键 词：纳米递送系统 光敏剂 光动力治疗 临床应用 联合治疗 

分 类 号：R944[医药卫生—药剂学]