聚富马酸丙二醇酯/聚三亚甲基碳酸酯复合材料的制备与表征  

Preparation and Characterization of Propylene Fumarate/Polytrimethylene Carbonate Composites

作　　者：丁俊杰 谢德明[1] DING Junjie;XIE Deming(Department of Biomedical Engineering,Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学生物医学工程系,广东广州510630

出　　处：《材料科学与工程学报》2023年第4期645-649,692,共6页Journal of Materials Science and Engineering

摘　　要：以N,N-羰基二咪唑(CDI)为活性剂,将羧基封端的聚三亚甲基碳酸酯(HO-PTMCCOOH,Mn=1964 g/mol)与聚富马酸丙二醇酯(PPF,Mn=1079 g/mol)偶联,成功合成了PPF与PTMC的新型复合材料。该复合材料的GPC测试表明数均分子量达到10357 g/mol。红外光谱仪(FTIR)、核磁共振波谱仪(1HNMR)表征证实了产物的组成与结构。产物经热固化后拉伸强度为(39.9±1.6)MPa。对该材料的降解性能以及细胞毒性进行评价,体外模拟降解28 d后其降解率达到12.07%(m/m),细胞毒性评估为1级毒性。N,N-Carbonyldiimidazole(CDI)was used as an active agent,carboxyl-terminated poly(trimethylene carbonate)(HO-PTMC-COOH,Mn=1964 g/mol)and poly(propylene fumarate)(PPF,Mn=1079 g/mol)as reacts,a new composite was successfully synthesized.GPC test of the composite showed that the number average molecular weight reached 10357 g/mol.FTIR and 1HNMR characterization confirmed the composition and structure of the product.The tensile strength of the product after thermal curing was(39.9±1.6)MPa.The degradation properties and cytotoxicity of the materials were also evaluated.After simulated degradation in vitro for 28 days,the degradation rate reached 12.07%(m/m),and the cytotoxicity was evaluated as grade 1 toxicity.

关 键 词：聚富马酸丙二醇酯 羧基封端聚三亚甲基碳酸酯 机械性能 生物降解高分子 

分 类 号：O632.12[理学—高分子化学]