加味麻杏石甘汤辅助治疗儿童甲型流行性感冒热毒袭肺证40例临床观察  

Clinical observation on 40 cases of influenza A in children with heat attacking the lung syndrome adjuvantly treated by modified Maxing Shigan Tang(麻杏石甘汤)

作　　者：李璐琦 黄永莲 王颖 李溦 杨一民[2] LI Luqi;HUANG Yonglian;WANG Ying;LI Wei;YANG Yimin(The Second Clinical School of Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,350108,China;Department of Pediatrics,Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Xiamen,Fujian,361009,China)

机构地区：[1]福建中医药大学第二临床医学院,福建福州350108 [2]福建中医药大学附属厦门市中医院儿科,福建厦门361009

出　　处：《中医儿科杂志》2023年第4期38-41,共4页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：厦门市中医院院内课题(XMSZYY202006)。

摘　　要：目的 观察加味麻杏石甘汤辅助治疗儿童甲型流行性感冒(甲流)热毒袭肺证的临床疗效。方法 选取2019年3月至2022年2月厦门市中医院儿科就诊的甲流热毒袭肺证患儿120例,依次编码为1~120号,逐一输入到SPSS 23.0软件分析系统产生120个随机数,对这120个随机数编秩次,秩次为1~40分到中医组,41~80分到西医组,81~120分到中西医组,各40例。中医组予加味麻杏石甘汤治疗,西医组予磷酸奥司他韦颗粒治疗,中西医组给予中医组和西医组的治疗方法,3组均治疗5 d后统计疗效,比较治疗前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)水平变化。结果 中西医组总有效率为90.0%(36/40),显著高于中医组和西医组的82.5%(34/40)、77.5%(31/40),两两比较,差异均有统计学意义(P<0.01)。治疗前3组血清TNF-α和IL-10水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后中医组、中西医组TNF-α水平较同组治疗前明显降低(P<0.05),中西医组IL-10水平较同组治疗前明显降低(P<0.05),且中西医组TNF-α和IL-10水平降低更显著(P<0.05)。结论 加味麻杏石甘汤辅助治疗儿童甲流热毒袭肺证,能显著降低TNF-α和IL-10水平,疗效满意,值得临床推广应用。Objective To observe the clinical efficacy of influenza A in children with heat attacking the lungs syndrome adjuvantly treated by modified Maxing Shigan Tang(麻杏石甘汤).Methods One hundred and twenty cases of children with influenza A and heat attacking the lung syndrome attending the pediatric department of Xiamen Traditional Chinese Medicine Hospital from March 2019 to February 2022 were selected and coded as numbers 1 to 120 in order,and entered into the SPSS 23.0 software analysis system one by one to generate 120 random numbers,and the 120 random numbers were coded with the rank order of 1 to 40 random numbers to the Chinese medicine group,41 to 80 to the Western medicine group,81 to 120 to the Chinese and Western medicine group,with 40 cases each.The Chinese medicine group was treated with Maxing Shigan Tang and the Western medicine group was treated with Oseltamivir phosphate granules.The Chinese and Western medicine groups were given both the treatment methods of the Chinese medicine group and the Western medicine group,and the efficacy of all three groups was counted after 5 days.The changes in serum tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)levels before and after treatment were compared.Results The total effective rate of the Chinese and Western medicine group was 90.0%(36/40),which was significantly higher than 82.5%(34/40)and 77.5%(31/40)of the Chinese medicine and Western medicine groups,and the differences were all statistically significant when comparing any two groups(P<0.01).The differences were not statistically significant(P>0.05)when comparing TNF-αand IL-10 levels in the three groups before treatment,and were comparable;after treatment,TNF-αlevels in the Chinese medicine group and the Chinese and Western medicine group were significantly lower than before treatment in the same group(P<0.05),and IL-10 levels in the Chinese and Western medicine group were significantly lower than before treatment in the same group(P<0.05),and the reduction of TNF-αand IL-10 levels was

关 键 词：甲型流行性感冒 儿童 热毒袭肺证 加味麻杏石甘汤 临床观察 

分 类 号：R254.9[医药卫生—中医内科学]