疏肝滋阴降火方对特发性中枢性性早熟阴虚火旺兼肝郁证女童骨龄和预测成年身高的影响  

The effect of Shugan Ziyin Jianghuo Fang(疏肝滋阴降火方)on bone age and predicting adult height in young girls with ICPP and flaring of fire due to yin-deficiency plus liver depression syndrome

作　　者：张晓莹[1] 郑小红[1] 邓雪梅[1] 马书鸽[1] ZHANG Xiaoying;ZHENG Xiaohong;DENG Xuemei;MA Shuge(Department of Traditional Chinese Medicine,Guangdong Maternal and Child Health Hospital,Guangzhou,Guangdong,501010,China)

机构地区：[1]广东省妇幼保健院中医科,广东广州501010

出　　处：《中医儿科杂志》2023年第4期52-56,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助项目(20211042)。

摘　　要：目的观察疏肝滋阴降火方对特发性中枢性性早熟(ICPP)阴虚火旺兼肝郁证女童骨龄(BA)和预测成年身高(PAH)的影响。方法选取2020年5月至2021年8月在广东省妇幼保健院中医科门诊确诊的ICPP阴虚火旺兼肝郁证女童60例,按随机数字表法分为对照组和治疗组,各30例。对照组予醋酸曲普瑞林冻干粉针(达菲林)肌肉注射,每4周1次,治疗组予中药疏肝滋阴降火方治疗。2组均3个月为1个疗程,连续治疗2个疗程后统计BA和PAH的变化情况。结果治疗3个月后,治疗组身高增长值(△H1)为(1.90±0.51)cm,对照组为(1.93±0.54)cm,2组比较,差异无统计学意义(P>0.05);治疗6个月后,治疗组身高增长值(△H2)为(2.15±0.49)cm,对照组为(1.19±0.47)cm,2组比较,差异有统计学意义(P<0.05);治疗6个月后,2组总身高增长值(△H3)比较,差异无统计学意义(P>0.05)。2组治疗6个月后BA增长速度均减缓,明显低于年龄的增长速度,2组的BA差值(△BA)/年龄差值(△CA)均明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05);组间比较,差异无统计学意义(P>0.05)。治疗6个月后2组的PAH均明显增加,与同组治疗前比较,差异均有统计学意义(P<0.05);组间比较,差异无统计学意义(P>0.05)。结论疏肝滋阴降火方治疗ICPP阴虚火旺兼肝郁证女童,可以有效减缓BA增长速度,改善PAH,临床疗效满意。Objective To observe the effect of Shugan Ziyin Jianghuo Fang(疏肝滋阴降火方)on bone age(BA)and predicted adult height(PAH)in young girls with idiopathic central precocious puberty(ICPP)and flaring of fire due to yin-deficiency plus liver depression syndrome.Methods Sixty young girls with ICPP and flaring of fire due to yin-deficiency plus liver depression syndrome who visited the Traditional Chinese Medicine Clinic of Guangdong Maternal and Child Health Hospital from May 2020 to August 2021 were selected and randomly divided into a control group and a treatment group,with 30 cases in each group.The control group was given intramuscular injection of triptorelin acetate lyophilized powder injection(dafilin)once every 4 weeks;The treatment group was treated with traditional Chinese medicine“Shugan Ziyin Jianghuo Fang”.Both groups were treated for 3 months as a course of treatment,and the changes in BA and PAH were recorded after 2 consecutive courses of treatment.Results After 3 months of treatment,the height growth value(△H1)of the treatment group was(1.90±0.51)cm,while that of the control group was(1.93±0.54)cm.There was no statistically significant difference between the two groups(P>0.05);After 6 months of treatment,the height increase value(△H2)of the treatment group was(2.15±0.49)cm,while that of the control group was(1.19±0.47)cm.The difference between the two groups was statistically significant(P>0.05).After 6 months of treatment,the total height increase(△H3)of the two groups was slightly higher in the treatment group than in the control group,but the difference was not statistically significant(P>0.05).After 6 months of treatment,the growth rate of BA in both groups slowed down,significantly lower than the growth rate of age.The BA difference(△BA)/age difference(△CA)in both groups decreased significantly,and the differences were statistically significant compared to before treatment in the same group(P<0.05);however,there was no statistically significant difference between groups

关 键 词：特发性中枢性性早熟 阴虚火旺兼肝郁证 女童 疏肝滋阴降火方 骨龄 预测成年身高 临床观察 

分 类 号：R725.8[医药卫生—儿科]