基于“脾主肌肉”理论探讨慢性肾脏病合并肌少症病因病机  

Approach to etiology and pathogenesis of chronic kidney disease-caused sarcopenia based on the theory of spleen nourishing the muscles

作　　者：王颖[1] 孔薇[2] WANG Ying;KONG Wei(Nanjing University of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学,南京210028 [2]南京中医药大学附属南京市中医院

出　　处：《山西中医》2023年第9期1-3,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：江苏省第四批省名老中医药专家传承工作室建设项目。

摘　　要：“脾主肌肉”理论与慢性肾脏病(CKD)合并肌少症密切相关,CKD伴有肌少症的主要病机是脾肾两虚。基于“脾主肌肉”理论,分析CKD合并肌少症的中医学病因病机以及现代医学机制,认为脾肾两虚可致骨骼肌线粒体异常、骨骼肌蛋白合成分解异常、骨骼肌Ca2+通路失常等,而致CKD合并肌少症的发生。The theory of spleen nourishing the muscles is closely related to chronic kidney disease(CKD)-caused sarcopenia.The main pathogenesis of CKD-caused sarcopenia is deficiency of both spleen and kidney.Based on the theory of spleen nourishing the muscles,the etiology and pathogenesis of TCM and modern medical mechanism of CKD-caused sarcopenia are analyzed.It is believed that deficiency of both spleen and kidney can lead to abnormal 2+skeletal muscle mitochondria,abnormal synthesis and decomposition of skeletal muscle protein and abnormal Ca pathway of skeletal muscle,so as to lead to the occurrence of CKD-caused sarcopenia.

关 键 词：慢性肾脏病 肌少症 脾主肌肉 病因病机 

分 类 号：R692[医药卫生—泌尿科学]