SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection  

作　　者：Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy Mirko Trilling Kathrin Sutter Mengji Lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu 

机构地区：[1]Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Institute for Virology,University Hospital of Essen,University of Duisburg-Essen,Essen,45147,Germany [3]Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,430022,China

出　　处：《Virologica Sinica》2023年第4期606-619,共14页中国病毒学（英文版）

基　　金：supported by the National Natural Science Foundation of China (92169105,82172256,81861138044,91742114 and M-0060);the Fundamental Research Funds for the Central Universities (2020kfyXGYJ028,2020kfyXGYJ046 and 2020kfyXGYJ016);the National Science and Technology Major Project (2017ZX10202203-007-006,2017ZX10202202-001-009,2017ZX10202202-002-008,2017ZX10202201-002-003);the Deutsche Forschungsgemeinschaft (DI 714/22-1,ZE 893/2-1,and RTG1949/2);the Medical Faculty of the University of Duisburg-Essen and Stiftung Universiatsmedizin,University Hospital Essen,Germany,and the Tongji-Rongcheng Center for Biomedicine,Huazhong University of Science and Technology。

摘　　要：A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82%and 76%,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75%of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.

关 键 词：COVID-19 SARS-CoV-2 T cell response CONVALESCENCE 

分 类 号：R563.1[医药卫生—呼吸系统]