基于数据挖掘探析古代湖湘医家与现代医家治疗癫痫的用药规律  

Medication rule of ancient Huxiang doctors and modern doctors in treatment of epilepsy:A study based on data mining

作　　者：王治栋 范建民[1] 张稳[1] WANG Zhidong;FAN Jianmin;ZHANG Wen(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖南中医杂志》2023年第6期27-32,共6页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省中医药科研计划项目(2021076、2021129);湖南省自然科学基金面上项目(2021JJ30528);湖南省中药粉体与创新药物研究省部共建国家重点实验室培育基地开放基金项目(21PTKF1026);湖南省科技厅临床医疗技术创新引导项目(2021SK51420);湖南省卫生健康委员会重点项目(C202303019464)。

摘　　要：目的:基于数据挖掘探析古代湖湘医家与现代医家治疗癫痫的用药规律。方法:挖掘《湖湘名医典籍精华》丛书及网络数据库中关于癫痫的医案,运用Excel 2010创建数据库并进行频次分析,采用SPSS 25.0进行聚类分析,采用SPSS Modeler 18.0、Venny 2.1.0进行关联规则与集合分析。结果:古代湖湘医家治疗癫痫的处方168首,中药226味;排前5位的药物依次为甘草、半夏、茯苓、朱砂、人参;排前3位的功效为补虚、清热、安神;排前3位的归经依次为脾、肺、心经;药物关联规则以半夏-陈皮药对支持度最高。现代医家治疗癫痫的处方93首,中药176味;排前5位的药物依次为半夏、甘草、茯苓、石菖蒲、天南星;排前3位的功效分别为平肝息风、补虚、化痰止咳平喘;排前3位的归经为肝、肺、脾经;药物关联规则以半夏-陈皮-茯苓药组支持度最高。两者药性均以寒、温、平为主,药味主要为苦、甘、辛。其共同关联药对及药组为陈皮、茯苓、半夏、甘草等药物之间的相互配伍。结论:古代湖湘医家治疗癫痫善补虚治本,重在补脾胃后天之本,兼顾祛湿化痰,若神机气乱,则需治神,标本兼顾。现代医家认为肝风内动致其病者多,故重视从肝论治,平肝息风。Objective:To investigate the medication rule of ancient Huxiang doctors and modern doctors in the treatment of epilepsy based on data mining.Methods:Data mining was performed for the series of Ancient Books and Records of Famous Huxiang Doctors and the medical records of epilepsy in online databases.Excel 2010 was used to establish a database and perform the frequency analysis,SPSS 25.0 was used to perform cluster analysis,and SPSS Modeler 18.0 and Venny 2.1.0 were used to perform the association rule analysis and the set analysis.Results:For the ancient Huxiang doctors,168 prescriptions involving 226 traditional Chinese medicine(TCM) drugs were obtained,with the top five drugs of Radix Glycyrrhizae,Pinellia ternata,Poria cocos,Cinnabaris,and Panax ginseng;the top three functions were tonifying deficiency,clearing heat,and tranquilizing mind;most drugs entered the spleen,lung,and heart meridians;the association rule analysis showed the highest degree of support for the Pinellia ternata-tangerine peel drug combination.For the modern doctors,93 prescriptions involving 176 TCM drugs were obtained,with the top five drugs of Pinellia ternata,Radix Glycyrrhizae,Poria cocos,Rhizoma Acori graminei,and Rhizoma Arisaematis;the top three functions were pacifying the liver and extinguishing wind,tonifying deficiency,and removing phlegm,relieving cough,and relieving asthma;most drugs entered the liver,lung,and spleen meridians;the association rule analysis showed the highest degree of support for the Pinellia ternata-tangerine peel-Poria cocos drug combination.Most drugs had a cold,warm or neutral nature and a bitter,sweet or pungent taste.The common drug combinations were the combination of the drugs including tangerine peel,Poria cocos,Pinellia ternata,and Radix Glycyrrhizae.Conclusion:In the treatment of epilepsy,ancient Huxiang doctors often applied deficiency-tonifying therapy to treat the root cause of a disease and emphasized tonifying the spleen and stomach as the acquired foundation,giving consideration to eliminatin

关 键 词：癫痫 古代湖湘医家 现代医家 用药规律 数据挖掘 

分 类 号：R277.721[医药卫生—中医学]