徐仕宏治疗急性加重期COPD用药规律探析  

Medication rule of Xu Shihong in treatment of acute exacerbation of chronic obstructive pulmonary disease

作　　者：杜峣楠 毛利 陈思言[1] 张婧 单采霞 杨丽[1] 徐仕宏 DU Yaonan;MAO Li;CHEN Siyan;ZHANG Jing;SHAN Caixia;YANG Li;XU Shihong(Nanchong Hospital of Traditional Chinese Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属南充市中医医院,四川南充637000

出　　处：《湖南中医杂志》2023年第6期33-37,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：四川省科技计划重点研发项目(2021YFS0270);四川省中医药管理局科学技术研究专项(2020LC0150);四川省南充市科技计划项目(19YFZJ0005)。

摘　　要：目的:采用数据挖掘的方法分析徐仕宏治疗急性加重期慢性阻塞性肺疾病(COPD)的用药规律。方法:收集2020年6月1日至2021年5月31日徐仕宏门诊诊治的急性加重期COPD病案,对处方药物进行频数、关联规则、聚类等分析。结果:共筛选出101首处方,包含中药127味。使用频次排前10位的中药分别为黄芩、桔梗、麻黄、紫菀、百部、金银花、甘草、杏仁、鱼腥草和黄连。关联规则分析结果显示,使用频次较高的药物组合有黄芩-石膏、麻黄-矮地茶、黄芩-黄连;黄芩-黄连-杏仁、黄芩-石膏-黄连、黄芩-石膏-紫菀;黄芩-黄连-杏仁-百部、黄芩-黄连-杏仁-麻黄、黄芩-黄连-杏仁-桔梗。对出现频次≥20次的药物进行聚类分析,挖掘出常用药对8对,可将药物聚为4类,总结出2首新处方:紫菀、百部、款冬花、麻黄、杏仁、矮地茶、鸡矢藤、黄连、石膏、金银花、穿心莲、荆芥、防风、豆蔻仁;射干、板蓝根、远志、鱼腥草。结论:徐仕宏主任医师治疗急性加重期COPD以清热化痰、宣降肺气、止咳平喘为基本治法,并重视肺胃同治,同时顾护肺阴。Objective:To investigate the medication rule of Xu Shihong in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD) based on data mining.Methods:Medical records were collected from the patients who were diagnosed and treated by Xu Shihong at the outpatient service from June 1,2020 to May 31,2021,and frequency analysis,association rule analysis,and cluster analysis were performed for the drugs in prescriptions.Results:A total of 101 prescriptions were obtained,involving 127 traditional Chinese medicine(TCM) drugs.The top 10 TCM drugs in terms of frequency were Scutellaria baicalensis,Platycodon grandiflorus,Ephedra sinensis,Aster tataricus,Radix Stemonae,Lonicera japonica,Radix Glycyrrhizae,Semen Armeniacae Amarum,Houttuynia cordata,and Coptis chinensis.The association rule analysis showed that the drug combinations with a relatively high frequency of use were Scutellaria baicalensis-Gypsum Fibrosum,Ephedra sinensis-Ardisiae Japonicae Herba,Scutellaria baicalensis-Coptis chinensis,Scutellaria baicalensis-Coptis chinensis-Semen Armeniacae Amarum,Scutellaria baicalensis-Gypsum Fibrosum-Coptis chinensis,Scutellaria baicalensis-Gypsum Fibrosum-Aster tataricus,Scutellaria baicalensis-Coptis chinensis-Semen Armeniacae Amarum-Radix Stemonae,Scutellaria baicalensis-Coptis chinensis-Ephedra sinensis,and Scutellaria baicalensis-Coptis chinensis-Semen Armeniacae Amarum-Platycodon grandiflorus.A cluster analysis was performed for the drugs with a frequency of ≥20,and 8 commonly used drug combinations were obtained;the drugs were clustered into 4 categories,and 2 new prescriptions were summarized,i.e.,Aster tataricus,Radix Stemonae,coltsfoot flower,Ephedra sinensis,Semen Armeniacae Amarum,Ardisiae Japonicae Herba,Paederia scandens,Coptis chinensis,Gypsum Fibrosum,Lonicera japonica,Andrographis paniculata,fineleaf Schizonepeta herb,Radix Saposhnikoviae,and Amomi Fructus Rotundus;blackberry lily rhizome,Radix Isatidis,Polygala tenuifolia,and Houttuynia cordata.Conclusion:In the treatment of acute e

关 键 词：COPD 急性加重期 用药规律 数据挖掘 徐仕宏 

分 类 号：R259.63[医药卫生—中西医结合]