手性金属有机框架材料NH_(2)-MIL-53(Al)-D-(+)-葡萄糖的液相色谱拆分性能研究  

Liquid Chromatographic Separation Performance of Chiral Metal-organic Framework Materials NH_(2)-MIL-53(Al)-D-(+)-glucose

作　　者：高顺秋 赖亚琳 蒋雪菲 普娜 袁黎明[1] GAO Shun-qiu;LAI Ya-lin;JIANG Xue-fei;PU Na;YUAN Li-ming(School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《化学试剂》2023年第9期76-82,共7页Chemical Reagents

基　　金：基于二维材料的薄片型气相色谱手性柱研究项目(22174125)。

摘　　要：金属有机框架材料(MOFs)因其具有特殊的拓扑结构、规则的单元排列、特定的孔道形状及尺寸、孔道结构及性质可调、表面可修饰等特点,被广泛应用于催化、分离和非线性光学等领域,其在手性分离分析领域也展现出其独特的应用价值。通过溶剂热法合成非手性MOFs(NH_(2)-MIL-53(Al)),再用D-(+)-葡萄糖对其进行手性修饰,最终合成了手性MOFs(NH_(2)-MIL-53(Al)-D-(+)-葡萄糖)。采用“网包法”制备了NH_(2)-MIL-53(Al)-D-(+)-葡萄糖固定相用于高效液相色谱(HPLC)手性柱,对其拆分能力进行考察。实验结果表明:NH_(2)-MIL-53(Al)-D-(+)-葡萄糖色谱柱拆分开了15种手性化合物和2种苯系位置异构体,其中共9个手性化合物和2种苯系位置异构体实现基线分离,且色谱柱具有良好的重复性,表明其分离效果良好。Metal-organic framework materials(MOFs)are widely used in catalysis,separation and nonlinear optics due to their special topological structure,regular unit arrangement,specific pore shape and size,adjustable pore structure and properties,and surface modification.They also show unique application values in the field of chiral separation and analysis.The chiral MOFs(NH_(2)-MIL-53(Al)-D(+)-glucose)were obtained by grafting D-(+)-glucose onto achiral MOFs(NH_(2)-MIL-53(Al))synthesized by solvothermal method.The NH_(2)-MIL-53(Al)-D-(+)-glucose stationary phase was prepared by“net-wrap method”for chiral column of high performance liquid chromatography(HPLC),and its resolution ability was investigated.The experimental results exhibited that the NH_(2)-MIL-53(Al)-D-(+)-glucose column had separated 15 chiral compounds and 2 benzene-based positional isomers.Among them,9 chiral compounds and 2 benzene-based positional isomers achieved baseline separation.Beside,the column had good repeatability,indicating that the separation effect was good.

关 键 词：金属有机框架材料 高效液相色谱 手性化合物 手性分离 手性固定相 

分 类 号：O657.7[理学—分析化学]