人子宫内膜类器官的研究进展及应用  

Research progress and application of human endometrium organoids

作　　者：李文文 邢琼[1] 王超[1] 魏兆莲[1] 王建业 Li Wenwen;Xing Qiong;Wang Chao;Wei Zhaolian;Wang Jianye(Reproductive Medicine Center,Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖中心,合肥230022

出　　处：《中华生殖与避孕杂志》2023年第8期842-846,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(81901437,82171619)。

摘　　要：子宫内膜类器官(endometrium organoids,EOs)是干细胞自组织形成的类似子宫内膜的三维培养物。EOs可以保留原始组织的生物学特性并且保持基因稳定,是一种新型体外模拟子宫内膜生理结构和功能的理想研究模型。随着生物技术和类器官培养方法的发展,EOs不仅可以用于子宫内膜发育研究,而且可用于妇科疾病模型、药物筛选、个体化诊疗及再生医学等研究领域。本文将从EOs的研究进展及应用前景等方面进行概述,以期推广EOs在基础和临床研究的应用。Endometrium organoids(EOs)are formed three-dimensional culture by self-organizing stem cells,which is similar to the endometrium in structure and function.EOs remain the biological characteristics of the original tissue and maintain gene stability,which are ideal research model to simulate the physiological structure and function of the endometrium in vitro.With the development of biotechnology and organoid culture methods,EOs can be used not only in endometrial development research,but also in gynecological disease models,drug screening,personalized diagnosis and treatment,and regenerative medicine.In order to popularize the EOs for the basic and clinical research,this review summarizd the research progress and application prospects of EOs.

关 键 词：子宫内膜 类器官 三维培养 妇科疾病 药物筛选 个性化医疗 再生医学 

分 类 号：R318.1[医药卫生—生物医学工程] R714[医药卫生—基础医学]