妊娠期女性癫痫患者的共患病现状及相关因素分析  

Status quo of comorbidity in women with epilepsy during pregnancy and analysis of its related factors

作　　者：薛亚妮 陈彭[1] 朱江[1] XUE Yani;CHEN Peng;ZHU Jiang(Department of Neurology,the First Hospital of Yulin,Yulin(719000),Shanxi,China)

机构地区：[1]榆林市第一医院神经内科,陕西榆林719000

出　　处：《癫痫与神经电生理学杂志》2023年第4期213-219,共7页Journal of Epileptology and Electroneurophysiology(China)

基　　金：榆林市科协青年人才托举计划资助项目(20200239)。

摘　　要：目的探讨妊娠期女性癫痫患者的共患病现状,并分析其相关危险因素。方法选取2018年2月至2020年2月就诊于榆林市第一医院神经内科及妇产科门诊的80例妊娠期女性癫痫患者,应用广泛性焦虑量表(GAD-7)、抑郁量表(NDDI-E)及匹兹堡睡眠质量指数量表(PSQI)进行评估,首先对妊娠期女性癫痫患者共患病的基线资料进行单因素分析,然后将筛选出的自变量进行二元logistic回归分析。结果80例妊娠期女性癫痫患者中有32例(40%)合并抑郁,31例(39%)合并焦虑,42例(52%)合并睡眠障碍。多因素分析显示病程及睡眠障碍是导致妊娠期女性癫痫患者伴发抑郁的独立危险因素(P<0.05);发作频率、抗癫痫发作药物(ASM)种类及睡眠障碍是导致妊娠期女性癫痫患者伴发焦虑的独立危险因素(P<0.05);抑郁及焦虑是导致妊娠期女性癫痫患者伴发睡眠障碍的危险因素(P<0.05)。结论妊娠期女性癫痫患者合并抑郁、焦虑及睡眠障碍的患病率较高。在临床工作中,需对这一类特殊人群的共患病做到早识别及早干预,适时调整ASM类型。Objective To investigate the status quo of comorbidity in women with epilepsy during pregnancy and analyze its related risk factors.Methods Eighty women with epilepsy during pregnancy were selected from outpatients at the Department of Neurology and the Department of Obstetrics and Gynecology,the First Hospital of Yuli from February 2018 to February 2020.Generalized anxiety disorder(GAD)-7,neurological disorders depression inventory for epilepsy(NDDI-E)scale,and Pittsburgh sleep quality index(PSQI)were applied to evaluate these patients.Firstly,univariate analysis was conducted on the baseline data of comorbidities among pregnant female patients with epilepsy,and then binary logistic regression analysis was performed on the screened independent variables.Results Of the 80 women with epilepsy during pregnancy,32 patients(40%)had depression,31 patients(39%)with anxiety and 42 patients(52%)with sleep disorder.Multivariate analysis showed that disease course and sleep disorder were independent risk factors for depression in women patients with epilepsy during pregnancy(P<0.05).Seizure frequency,types of anti-seizure drugs(ASM)and sleep disorder were independent risk factors for anxiety in women patients with epilepsy during pregnancy(P<0.05).Depression and anxiety were the risk factors of sleep disorder in pregnant women with epilepsy(P<0.05).Conclusion The prevalence of depression,anxiety and sleep disorder in women with epilepsy during pregnancy is high.In clinical practice,early identification and intervention are needed for comorbidities in this special group of people,and ASM types will be adjusted in a timely manner.

关 键 词：妊娠期 癫痫 共患病 焦虑 抑郁 睡眠障碍 

分 类 号：R714.1[医药卫生—妇产科学] R742.1[医药卫生—临床医学]