我国22家采供血机构献血人群HCV检测不合格情况调查分析  

Analysis of the unqualified HCV detection results of blood donors from the served area of 22 domestic blood institutions

作　　者：杨忠思 许守广 张微 张剑 刘晓杰 燕锋[6] 王琴 何燕琴 鲍琳 于志强[10] 王振兴[11] 邱昌文 蔡晓波[13] 李丽[14] 汪鹏 徐战锋 于福荣 赵超[18] 王建康[19] 沈有华 鲍晶晶[21] 周君 邱艳[23] Yang Zhongsi;Xu Shouguang;Zhang Wei;Zhang Jian;Liu Xiaojie;Yang Feng;Wang Qin;He Yanqin;Bao Lin;Yu Zhiqiang;Wang Zhenxing;Qiu Changwen;Cai Xiaobo;Li Li;Wang Peng;Xu Zhanfeng;Yu Furong;Zhao Chao;Wang Jiankang;Shen Youhua;Bao Jingjing;Zhou Jun;Qiu Yan(Qingdao Central Blood Station,Laboratory Department,Qingdao 266073,China;Yangzhou Central Blood Station,Laboratory Department,Yangzhou 225007,China;Tongzhou Central Blood Station,Laboratory Department,Beijing 101117,China;Yancheng Central Blood Station,Laboratory Department,Yancheng 224055,China;Qinhuangdao Blood Center,Laboratory Department,Qinhuangdao 066001,China;Handan Central Blood Station,Laboratory Department,Handan 056005,China;Jiujiang Central Blood Station,Laboratory Department,Jiujiang 332099,China;Ganzhou Central Blood Station,Laboratory Department,Ganzhou 341001,China;Yichun Central Blood Station,Laboratory Department,Yichun 336028,China;Luoyang Central Blood Station,Laboratory Department,Luoyang 471099,China;Dongguan Central Blood Station,Laboratory Department,Dongguan 523930,China;Nanning Central Blood Station,Laboratory Department,Nanning 530003,China;Taizhou Central Blood Station,Laboratory Department,Taizhou 225306,China;Huaian Central Blood Station,Laboratory Department,Huaian 223021,China;Bijie Central Blood Station,Laboratory Department,Bijie 551799,China;Puyang Central Blood Station,Laboratory Department,Puyang 457005,China;Chifeng Central Blood Station,Laboratory Department,Chifeng 024099,China;Baoding Central Blood Station,Laboratory Department,Baoding 071051,China;Baoji Central Blood Station,Laboratory Department,Baoji 721013,China;Shangrao Central Blood Station,Laboratory Department,Shangrao 334099,China;Nanjing Central Blood Station,Laboratory Department,Nanjing 210042,China;Xianyang Central Blood Station,Laboratory Department,Xianyang 712046,China;Beijing Red Cross Blood,Laboratory Department,Beijing 100088,China)

机构地区：[1]青岛市中心血站检验科,青岛266073 [2]扬州市中心血站检验科,扬州225007 [3]北京市通州区中心血站检验科,北京101117 [4]盐城市中心血站检验科,盐城224055 [5]秦皇岛市中心血站检验科,秦皇岛066001 [6]邯郸市中心血站检验科,邯郸05600 [7]九江市中心血站检验科,九江332099 [8]赣州市中心血站检验科,赣州341001 [9]宜春市中心血站检验科,宜春336028 [10]洛阳市中心血站检验科,洛阳47109 [11]东莞市中心血站检验科,东莞523930 [12]南宁中心血站检验科,南宁530003 [13]泰州市中心血站检验科,泰州225306 [14]淮安市中心血站检验科,淮安223021 [15]毕节市中心血站检验科,毕节551799 [16]濮阳市中心血站检验科,濮阳457005 [17]赤峰市中心血站检验科,赤峰024099 [18]保定市中心血站检验科,保定071051 [19]宝鸡市中心血站检验科,宝鸡721013 [20]上饶市中心血站检验科,上饶334099 [21]南京红十字血液中心检验科,南京210042 [22]咸阳市中心血站检验科,咸阳712046 [23]北京市红十字血液中心检验科,北京100088

出　　处：《中华实验和临床病毒学杂志》2023年第4期367-372,共6页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的调查分析我国采供血机构(简称机构)服务区域献血人群丙型肝炎病毒(hepatitis C virus,HCV)检测不合格情况。方法收集2017—2021年我国内地采供血机构执业比对系统内初次献血和重复献血人群HCV相关标记物检测数据,分析每10万献血者中抗-HCV和抗-HCV阴性中HCV RNA检测不合格率与年度、采供血服务区域以及初次献血和重复献血人群之间的关系。结果2017—2021年间22家机构服务区域的每10万献血者中抗-HCV不合格例数从444.3逐年减少至250.44(χ^(2)=49.677,P<0.05);HCV RNA检出例数从0.69逐年增加至2.05,但无统计学意义(χ^(2)=0.643,P>0.05);区域间的抗-HCV不合格率差异有统计学差异(χ^(2)=3260.283,P<0.05);初次献血人群的抗-HCV不合格率明显高于重复献血人群(F=130.993,P<0.05);每10万名抗-HCV合格献血者HCV RNA每年检出例数范围为0~17.28。结论我国22家机构服务区域献血者的抗-HCV不合格率呈逐年降低趋势;与重复献血人群相比,应重视初次献血人群的HCV感染;针对部分机构献血者应重视HCV检测,HCV RNA检测可以进一步检出血清学漏检的HCV感染者。Objective To investigate the unqualified hepatitis C virus(HCV)detection result of blood donors from the served area of blood institutions.Methods The data related to HCV markers detected of the first and repeat blood donors were collected from the system of practice comparison for the Chinese mainland blood institutions from 2017 to 2021.The anti-HCV reactive rate and the rates of anti-HCV negative but HCV-RNA reaction and all the relationship between rates and the annual,regional and different blood donors were statistically analyzed.Results During 2017-2021,the number of anti-HCV reactive per 100000 blood donors decreased from 444.3 to 250.44 in the served area of 22 blood institutions(χ2=49.677,P<0.05).The number of HCV RNA detected positive per 100000 anti-HCV negative increased from 0.69 to 2.05 year by year,but there was no statistical significance(χ2=0.643,P>0.05).The anti-HCV unqualified rate was significantly different among regions(χ2=3260.283,P<0.05).The anti-HCV unqualified rate of the first blood donors was significantly higher than that of the repeated blood donors(F=130.993,P<0.05).The annual number of HCV RNA detected positive per 100000 anti-HCV negative blood samples from donors ranged from 0 to 17.28.Conclusions The anti-HCV unqualified rate of blood donors in the served area of 22 blood institutions decreased year by year.Compared with repeated blood donors,HCV infection should be emphasized in first-time blood donors.The implementation of HCV RNA test can detect out much more HCV infections and reduce the risk of transfusion transmitted infectious HCV.

关 键 词：丙型肝炎病毒 抗-HCV ELISA 核酸检测 初次献血者 

分 类 号：R457.1[医药卫生—治疗学] R512.63[医药卫生—临床医学]