Mobius自动验证系统在容积旋转调强放疗验证中的应用研究  

Research on Application of Mobius Automatic Verification System in the Verification of Volumetric Modulated Arc Therapy

作　　者：袁维[1] 张月美 路咏凯 何瑞欣 唐丰文 李毅[1] YUAN Wei;ZHANG Yuemei;LU Yongkai;HE Ruixin;TANG Fengwen;LI Yi(Department of Oncology Radiotherapy,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an Shaanxi 710061,China)

机构地区：[1]西安交通大学第一附属医院放疗科,陕西西安710061

出　　处：《中国医疗设备》2023年第9期31-35,共5页China Medical Devices

基　　金：陕西省重点研发计划一般项目(2022SF-440)。

摘　　要：目的探究Mobius自动验证系统在容积旋转调强放射治疗(Volumetric Modulated Arc Therapy,VMAT)计划验证的应用可行性。方法随机选择2021年4月至2022年1月在西安交通大学第一附属医院接受VMAT的不同部位肿瘤患者90例,分别实行Mobius和Delta4两种方法验证,统计不同部位两种算法靶区剂量学差异与多个标准下γ通过率,评估Mobius软件在不同部位VMAT计划验证中的精确性与可行性。结果两种系统不同算法下靶区平均剂量和90%覆盖度之间的差异均满足临床剂量学差异要求(<3%),不同部位差异有统计学意义(P<0.05),其中盆腔部位剂量差异最小;3%/3mm标准时两种验证设备VMAT验证γ通过率均能满足临床验证要求(γ>95%),除胸部计划外,Mobius与Delta4设备在3%/3 mm、3%/2 mm、2%/2 mm这3种γ评估标准下均具有良好的一致性(P>0.05),但验证未能通过2%/2 mm临床标准(γ<90%)。结论3%/3 mmγ评估标准下,Mobius自动验证系统与基于模体的Delta4验证设备具有良好的一致性,可以应用于VMAT计划验证,但不同部位肿瘤计划间差异需要注意。Objective To explore the application feasibility of Mobius automatic verification system in the verification of volumetric modulated arc therapy(VMAT).Methods A total of 90 patients receiving VMAT for tumors at different sites in the First Affiliated Hospital of Xi’an Jiaotong University from April 2021 to January 2022 were randomly selected.Mobius and Delta4 methods were used to verify the dosimetry differences in the target area of the two algorithms at different sites and theγpassing rate under multiple criteria were calculated.The accuracy and feasibility of Mobius software in the verification of VMAT plans for different anatomical sites were evaluated.Results The discrepancies of two algorithms of verification systems the in mean dose and 90%coverage of the planning target volume all met the requirements of clinical dosimetric differences(<3%),and the difference between different sites was statistically significant(P<0.05),of which the dose discrepancies in the pelvis was the smallest.When the 3%/3 mm criteria was used,the VMATγpassing rates of the two verification devices could meet the clinical verification requirements(γ>95%).Theγpassing rate of two systems in the criteria of 3%/3 mm,3%/2 mm,2%/2 mm had a good consistency(P>0.05)except the chest VMAT plan.But the validation failed to pass the 2%/2 mm clinical standard(γ<90%).Conclusion When utilizing the 3%/3 mmγpassing rate evaluation standard,the Mobius automatic verification system had a good consistency with the Delta4 verification device based on the phantom,however,the deviations between different anatomical site should be noted.

关 键 词：MOBIUS Delta4 容积旋转调强放射治疗 靶区剂量学 计划验证 

分 类 号：R144[医药卫生—公共卫生与预防医学] R730.55