免疫层析信号放大技术及其在生物医药领域应用的研究进展  

Research progress of immunochromatographic signal amplification technology and its application in biomedical fields

作　　者：贾轶静 唐毓婧[1] 李晓敏 邓莹楠 周陇 郭子芳[1] JIA Yijing;TANG Yujing;LI Xiaomin;DENG Yingnan;ZHOU Long;GUO Zifang(Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials,Sinopec(Beijing)Research Institute of Chemical Industry Co.,Ltd.,Beijing 100013,China)

机构地区：[1]中石化(北京)化工研究院有限公司中国石化医用卫生材料研究与应用重点实验室,北京100013

出　　处：《石油化工》2023年第8期1176-1182,共7页Petrochemical Technology

摘　　要：免疫层析技术由于具有操作简便、快速、灵敏度和选择性好、操作成本低、无需专业技术人员协助等特点,已广泛应用于生物分析、疾病诊断、药物残留检测及食品安全等领域。重点介绍了免疫层析技术的原理、基于免疫标记材料以及免疫测定模式设计的信号放大策略,综述了该技术在生物医药领域的应用研究进展,并对免疫层析技术未来的发展方向以及在即时检测方面的应用价值进行了展望。Immunochromatographic assay(ICA)has been widely used in biological analysis,disease diagnosis,drug residue detection,food safety and other fields because of its advantages such as simplicity,rapid operation,good sensitivity and selectivity,low cost,and no need for professional technical assistance.In this paper,the principle of ICA,the signal amplification strategy based on immunolabeling materials and immunoassay pattern design are mainly described,the application research progress of ICA in the field of biomedicine is reviewed,and the future development direction of ICA and its application value in point-of-care testing are prospected.

关 键 词：免疫层析 免疫标记材料 信号放大 生物医药 

分 类 号：R446.6[医药卫生—诊断学]