外泌体在心肌梗死治疗中的研究新进展  

New research progress of exosomes in the treatment of myocardial infarction

作　　者：侯永波 余骏马 朱海娟[3] HOU Yongbo;YU Junma;ZHU Haijuan(College of Anesthesiology-Wannan Medical College,Wuhu 241002,China;Department of Anesthesiology,the Third Affiliated Hospital of Anhui Medical University,Hefei First People's Hospital;Department of Anesthesiology,Maternal and Child Health Hospital Affiliated to Anhui Medical University)

机构地区：[1]皖南医学院麻醉学院,241002 [2]安徽医科大学第三附属医院(合肥市第一人民医院)麻醉科 [3]安徽医科大学附属妇幼保健院麻醉科

出　　处：《天津医药》2023年第9期1016-1020,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(82100315)。

摘　　要：心肌梗死是致死率较高的疾病之一,且疾病后期进展常导致慢性心力衰竭的发生,探索新的治疗方法对于心肌梗死的预后十分重要。外泌体是由细胞或组织液释放的直径为30~150 nm的纳米级囊泡,其囊泡内携带着来自亲代细胞分泌的特异DNA、RNA、蛋白质、脂质和代谢废物等物质,其作为心肌梗死的潜在治疗方法在基础实验中早已被证实。就不同细胞组织来源的外泌体、工程化外泌体以及外泌体细胞膜融合策略在心肌梗死治疗中的研究进展进行综述,为外泌体在临床上的应用提供科学证据。Myocardial infarction is one of the most lethal diseases,and the progression of the disease often leads to the occurrence of chronic heart failure.Therefore,it is very important to explore new treatment methods for the prognosis of myocardial infarction.Exosomes are nanoscale vesicles with a diameter of 30-150 nm released from cells or tissue fluid.The vesicles carry specific DNA,RNA,proteins,lipids,metabolic waste and other substances secreted by parental cells.As a potential treatment for myocardial infarction,it has long been confirmed in basic experiments.This article reviews the latest research progress of exosomes from different cells and tissues,engineered exosomes and exosome cell membrane fusion strategies in the treatment of myocardial infarction,and provides scientific evidence for the clinical application of exosomes.

关 键 词：心肌梗死 外泌体 间质干细胞 成纤维细胞 巨噬细胞 膜融合 微RNAS 

分 类 号：R541[医药卫生—心血管疾病]