血清肌酸激酶同工酶、肌钙蛋白、BNP在急性心肌梗死患者中的表达及预测价值分析  

Expression and predictive value of serum creatine kinase isoenzyme,troponin and BNP in patients with acute myocardial infarction

作　　者：罗涛 肖叙平 童玲[1] 李连业 Luo Tao;Xiao Xuping;Tong Ling;Li Lianye(Taihe County People's Hospital,Ji'an,Jiangxi 343700,China)

机构地区：[1]江西省泰和县人民医院,江西吉安343700

出　　处：《首都食品与医药》2023年第16期61-63,共3页Capital Food Medicine

摘　　要：目的探讨血清肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnI)、脑钠肽(BNP)在急性心肌梗死(AMI)患者中的表达及对AMI的预测价值。方法分别选取泰和县人民医院收治的AMI患者106例和稳定性心绞痛(SAP)患者90例,分别纳入AMI组和SAP组。比较两组患者的临床资料,采用多因素Logistic回归模型分析影响AMI发生的危险因素。以受试者工作特征曲线(ROC)分析血清CK-MB、cTnI、BNP对AMI产生的预测价值。结果AMI组患者中吸烟史占比、高血压占比、病变支数≥2支占比及低密度脂蛋白胆固醇(LDL-C)、CK-MB、cTnI、BNP水平均高于SAP组,左心室射血分数(LVEF)水平则低于SAP组(P<0.05)。多因素Logistic回归模型显示高水平LDL-C及CK-MB、cTnI、BNP均是影响AMI发生的危险因素(P<0.05)。ROC曲线分析显示,血清CK-MB、cTnI、BNP及三项指标联合预测AMI发生的AUC分别为0.796、0.815、0.802、0.946,三项指标联合预测效能高于单项指标(P<0.05)。结论AMI患者中血清CK-MB、cTnI、BNP均为高水平表达,且该三项指标均是影响AMI发生的危险因素,三者联合对AMI发生的预测具有较高效能。Objective To investigate the expression of serum creatine kinase isoenzyme(CK-MB),troponin(cTnI)and brain natriuretic peptide(BNP)in patients with acute myocardial infarction(AMI)and the predictive value of AMI.Methods 106 patients with AMI admitted to our hospital and 90 patients with stable angina pectoris(SAP)admitted to our hospital were selected and divided into AMI group and SAP group.The clinical data of the two groups were compared,and the risk factors of AMI were analyzed by multiple Logistic regression model.The predictive value of serum CK-MB,cTnI and BNP on AMI generation was analyzed by receiver operating characteristic curve(ROC).Results The proportion of smoking history,the proportion of hypertension,the number of lesions≥2 and the levels of low-density lipoprotein cholesterol(LDL-C),CK-MB,cTnI and BNP in AMI group were higher than those in SAP group.The level of left ventricular ejection fraction(LVEF)was lower than that of SAP group(P<0.05).Multiple Logistic regression model showed that LDL-C,CK-MB,cTnI and BNP in Killip grade were all risk factors for AMI occurrence(P<0.05).ROC curve analysis showed that,The AUC of serum CK-MB,cTnI and BNP and their combined prediction of AMI were 0.796,0.815,0.802 and 0.946,respectively.The combined prediction efficiency of three indexes was higher than that of one index(P<0.05).Conclusion Serum CK-MB,cTnI and BNP were all expressed at high levels in AMI patients,and the three indexes were all risk factors affecting the occurrence of AMI.The combination of the three indexes had high efficacy in predicting the occurrence of AMI.

关 键 词：急性心肌梗死 肌酸激酶同工酶 肌钙蛋白 脑钠肽 预测 

分 类 号：R542.22[医药卫生—心血管疾病]