妊娠期用药与不良妊娠结局的相关性  

The Correlation between Medication during Pregnancy and Adverse Pregnancy Outcomes

作　　者：刘媛 汪艳影 向少能 徐清华 LIU Yuan;WANG Yan-Ying;XIANG Shao-Neng;XU Qing-Hua(Department of Pharmacy,Jianyang maternal and child health hospital,Jianyang 641400,Sichuan China;Department of Clinical Medicine,Jianyang chinese medicine hospital,Jianyang 641400,Sichuan China)

机构地区：[1]简阳市妇幼保健院药剂科,四川简阳641400 [2]简阳市中医医院临床药学科,四川简阳641400

出　　处：《中国药物经济学》2023年第7期75-79,共5页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨妊娠期用药与不良妊娠结局的相关性。方法 统计2018年10月至2021年9月于简阳市妇幼保健院门诊进行妊娠期用药咨询孕妇的用药现状,并对新生儿出生情况进行随访。结果 前来咨询的516人次中,54.84%为拟生育二胎者。在药物使用时期方面,受精后1~8周使用药物的人群最多占84.49%。共咨询443种药物,频率最高的3类药物为中成药及中草药、抗感染药物及中枢神经系统药物。咨询次数排名前3位的药物是新型冠状病毒疫苗、阿莫西林、奥美拉唑。根据随访结果,咨询人员中141例失访、242例正常、124例人流、7例自发流产或胎停、2例出现畸形或异常。其中随访的接种新型冠状病毒疫苗的咨询者中,选择继续妊娠的均分娩正常新生儿。结论 90%以上孕期用药为未知妊娠的意外暴露,且生育二胎的女性为主要人群。加强育龄女性合理用药的宣传,做好孕期用药咨询、研究,对优生优育,减少人流具有重要意义。Objective To explore the correlation between medication during pregnancy and adverse pregnancy outcomes.Methods The status quo of drug use among pregnant women consulted in the pregnancy medication consultation clinic of Jianyang Maternal and Child Health Hospital from October 2018 to September 2021 was analyzed,and the birth status of newborns was followed up.Results Of the 516 people who came for consultation,54.84% were planning to have a second child.In terms of drug use period,84.49% of the population used drugs within 1~8 weeks after fertilization.A total of 443 kinds of drugs were consulted,and the three most frequently used drugs were Chinese patent medicine and Chinese herbal medicine,anti infective drugs and central nervous system drugs.The top three consultation times are Xinguan vaccine,amoxicillin and omeprazole.According to the follow-up results,141 cases of lost follow-up,242 cases of normal,124 cases of abortion,7 cases of spontaneous abortion or fetal stop,2 cases of deformity or abnormality.Among the follow-up consultants who received the new crown vaccine,those who chose to continue their pregnancy all delivered normal newborns.Conclusion More than 90% of the drugs used during pregnancy are accidental exposure of unknown pregnancy,and the women who have two children are the main population.It is of great significance to strengthen the publicity of rational drug use among women of childbearing age,and do a good job in consultation and Research on drug use during pregnancy,so as to promote the birth and child-bearing and reduce abortion.

关 键 词：妊娠期 药物 咨询 新型冠状病毒疫苗 

分 类 号：R951[医药卫生—药学] R7110