肾损伤标志物在肾综合征出血热合并急性肾损伤中可能的致病机制研究进展  

Research Progress on Possible Pathogenesis of Renal Injury Markers in Hemorrhagic Fever with Renal Syndrome complicated with Acute Renal Injury

作　　者：黄晶晶 王闯 高鸾[3] 王惠琦 张晓东 何花 HUANG Jing-jing;WANG Chuang;GAO Luan;WANG Hui-Qi;ZHANG Xiao-Dong;HE Hua(Department of Infectious Diseases,Hongqi Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 15701l,China;Department of Neurosurgery,Hongqi Hospital affiliated to Mudanjiang Medical College,Mudanjiang 15701l,China;Nursing College of Mudanjiang Medical College,Mudanjiang 15701l,China)

机构地区：[1]牡丹江医学院附属红旗医院感染科,黑龙江牡丹江157011 [2]牡丹江医学院附属红旗医院神经外科,黑龙江牡丹江157011 [3]牡丹江医学院护理学院,黑龙江牡丹江157011

出　　处：《中国药物经济学》2023年第7期104-107,113,共5页China Journal of Pharmaceutical Economics

基　　金：2020年度黑龙江省省属高等学校基本科研业务费科研项目(2020-KYYWF-0753)。

摘　　要：肾综合征出血热(HFRS)至今发病机制不明,且无特异性疗法,但HFRS患者发生急性肾损伤(AKI)贯穿病程始终,也是致死的重要原因之一。然而,现有的诊断肾损伤的标志物对早期AKI诊断的敏感性较低。因此探索敏感性及特异性较高的标志物诊断AKI,明确HFRS患者AKI进程,尽早采取合理的治疗措施,是改善患者预后的关键。本文对肾损伤标志物肝脏脂肪酸结合蛋白(L-FABP)、肾损伤分子-1(KIM-1)、补体C1q在HFRS合并AKI中的可能致病机制进行综述,旨在为临床早期诊断AKI提供参考。Hemorrhagic fever with renal syndrome(HFRS)has unknown pathogenesis and no specific treatment.However,acute kidney injury(AKI)occurs throughout the course of HFRS,which is also one of the important causes of death.However,existing markers for the diagnosis of renal injury are less sensitive to the early diagnosis of AKI.Therefore,the key to improve the prognosis of HFRS patients is to explore markers with high sensitivity and specificity for the diagnosis of AKI,to clarify the process of AKI in HFRS patients,and to take reasonable treatment measures as early as possible.This article reviews the possible pathogenic mechanism of renal injury markers Liver fatty acid binding protein(L-FABP),kidney injury molecule-1(KIM-1)and complement C1q in hemorrhagic fever with renal syndrome complicated with AKI,so as to provide reference for early clinical diagnosis of AKI.

关 键 词：肾综合征出血热 急性肾损伤 肝脏脂肪酸结合蛋白 肾损伤分子-1 补体C1Q 

分 类 号：R512.8[医药卫生—内科学] R692.9[医药卫生—临床医学]