Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects  

作　　者：Akansha Shrivastava Mamta Pal Rakesh Kumar Sharma 

机构地区：[1]Department of Biosciences,Manipal University Jaipur,Jaipur 303007,India [2]Sardar Swaran Singh National Institute of Bio-Energy,Jalandhar 144601,India

出　　处：《Journal of Bioresources and Bioproducts》2023年第2期108-124,共17页生物质资源与工程（英文）

摘　　要：Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and pharmaceuticals.For a variety of biotechnological production hosts,a few specific genera of yeast have proven themselves.Rapid developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these substances.In this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia species.Cutting-edge solutions involving genetic and process engineering have also been discussed.Overall,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like Pichia.The processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关 键 词：Natural product PICHIA Non-conventional yeast BIOSYNTHESIS System biology Synthetic biology 

分 类 号：F426[经济管理—产业经济]