基于数据挖掘的半夏炮制品辨证治疗失眠的用药规律分析  

Medication Rules of Pinelliae Rhizoma Processed Products in Syndrome Differentiation and Treatment of Insomnia Based on Data Mining

作　　者：杨锦妮 陆忠文 滕飞 张艳[1] YANG Jinni;LU Zhongwen;TENG Fei;ZHANG Yan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2023年第18期165-174,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82174117);山东省自然科学基金重大基础项目(ZR2019ZD23);山东省中医药科技发展计划项目(2019-0034);山东省研究生教育优质课程项目(SDYKC21050)。

摘　　要：目的:数据挖掘方法分析总结半夏不同炮制品辨证治疗失眠的用药规律。方法:检索中国知网、维普、PubMed数据库中近10年半夏治疗失眠的文献,Excel软件构建半夏不同炮制品治疗失眠的方剂数据库,SPSS 26.0频次分析失眠的中医证型、配伍药物及其功效与性能,SPSS 26.0进行聚类分析、因子分析及Modeler 18.0插件关联规则分析半夏不同炮制品核心配伍药物及组方。结果:按照纳入与排除标准筛选文献,最终纳入文献125篇,法半夏、姜半夏、清半夏为半夏治疗失眠常用炮制品,尤以法半夏最常用。3种炮制品均多用于痰热扰心、痰湿内阻、肝气郁结型失眠,配伍味甘苦辛寒,归肺、脾、心、肝经的补虚、清热、安神之品,常组成温胆汤、柴胡加龙骨牡蛎汤、半夏泻心汤、小柴胡汤使用,剂量6~30 g,法半夏-茯苓-酸枣仁、姜半夏-大枣-党参、清半夏-黄芩-柴胡为核心药物组合。结论:该研究首次从中医辨证角度,分析总结了半夏治疗失眠常用炮制品的配伍组方应用规律,为中医药合理安全有效地使用半夏治疗失眠提供了理论依据。Objective:To analyze and summarize the medication rules of different Pinelliae Rhizoma processed products in the syndrome differentiation and treatment of insomnia using data mining.Method:The literature on the treatment of insomnia with Pinelliae Rhizoma was retrieved from the China National Knowledge Infrastructure(CNKI),VIP,and PubMed databases over the past 10 years.An Excel database was constructed to record the prescriptions of different Pinelliae Rhizoma processed products in the treatment of insomnia.SPSS 26.0 software was used for frequency analysis of traditional Chinese medicine(TCM)syndromes related to insomnia,compatibility of drugs,drug effects,and properties.SPSS 26.0 was also used for cluster analysis,factor analysis,and IBM Modeler 18.0 plugin for association rule analysis of the core compatibility of different Pinelliae Rhizoma processed products and combinations.Result:After applying inclusion and exclusion criteria,125 relevant articles were finally included.The commonly used processed products of Pinelliae Rhizoma in the treatment of insomnia were Pinelliae Rhizoma Praeparatum,Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine,and Pinelliae Rhizoma Praeparatum cum Alumine.Among them,Pinelliae Rhizoma Praeparatum was the most frequently used.All three processed products of Pinelliae Rhizoma were often used for insomnia with such TCM syndromes as phlegm-heat disturbing the heart,phlegm-dampness obstructing the interior,and liver Qi stagnation.The compatible drugs were sweet,bitter,and pungent in flavor,cold in nature,and acted on the lung,spleen,heart,and liver meridians,with functions of nourishing deficiency,clearing heat,and calming the mind.The common prescriptions used were Wendantang,Chaihu Longgu Mulitang,Banxia Xiexintang,and Xiaochaihutang,with doses ranging from 6 to 30 g.The core drug combinations were Pinelliae Rhizoma Praeparatum-Poria-Ziziphi Spinosae Semen,Pinelliae Rhizoma Praeparatum Cum Zingibere et Alumine-Jujubae Fructus-Codonopsis Radix,and Pinelliae Rhizoma Praeparatum

关 键 词：数据挖掘 半夏 中医辨证 失眠 用药规律 

分 类 号：R284.2[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24