NLRP3炎症小体在骨关节疾病中的作用及中医药干预进展  

Role of NLRP3 Inflammasome in Bone and Joint Diseases and Traditional Chinese Medicine Intervention:A Review

作　　者：李向洲 邢涛[2] 钱朝良 韩李霞 杨博 LI Xiangzhou;XING Tao;QIAN Chaoliang;HAN Lixia;YANG Bo(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730050

出　　处：《中国实验方剂学杂志》2023年第18期241-250,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省自然科学基金项目(17JR5RA054,22JR5RA628)。

摘　　要：核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体是一种细胞内感应蛋白复合物,是先天免疫系统的重要参与者,可感知外来病原体和内源性危险信号。组织损伤后,NLRP3炎症小体的激活诱导促炎细胞因子白细胞介素(IL)-1β和IL-18的释放,同时促进消皮素D介导细胞焦亡。现有研究表明,NLRP3炎症小体通过诱发炎症级联反应、加速骨吸收和软骨破坏等形式在骨质疏松症、骨关节炎、类风湿性关节炎、痛风性关节炎等常见骨关节疾病发生及发展中发挥关键作用。因此,阻断NLRP3炎症小体信号通路可能成为治疗或预防骨关节疾病的有效策略。目前,研究人员在动物和临床研究中开发和测试了几种选择性靶向NLRP3炎症小体的药物,但由于不良反应明显、价格昂贵等原因导致进展不佳。中医药因其多靶点、多通路、多机制协同作用及价格低廉、不良反应低等独特优势在骨关节疾病的治疗中得到普遍认可。随着研究不断深入,中医药靶向干预NLRP3炎症小体治疗骨关节疾病受到广泛关注。该文通过分析整理近年来国内外相关文献,总结阐述NLRP3炎症小体在骨关节炎中的作用机制,并进一步对中医药靶向干预NLRP3炎症小体治疗骨关节疾病进展进行系统综述,以期为骨关节疾病的治疗提供新的思路及理论依据。Nucleotide binding oligomeric dome-like receptor protein 3(NLRP3)inflammasome is an intracellular sensing protein complex,and it is an important player in the innate immune system,capable of sensing foreign pathogens and endogenous danger signals.After tissue injury,the activation of the NLRP3 inflammasome induces the release of the pro-inflammatory cytokines interleukin(IL)-1βand IL-18,while promoting gasdermin D-mediated pyroptosis.Existing studies have shown that NLRP3 inflammasome plays a key role in the occurrence and development of common bone and joint diseases such as osteoporosis,osteoarthritis,rheumatoid arthritis,and gouty arthritis by inducing inflammatory cascade reaction and accelerating bone resorption and cartilage destruction.Therefore,blocking the NLRP3 inflammasome signaling pathway may be an effective strategy to treat or prevent bone and joint diseases.Currently,researchers have developed and tested several drugs that selectively target the NLRP3 inflammasome in animal and clinical studies,but the progress has been poor due to obvious side effects and high prices.Traditional Chinese medicine(TCM)has been widely recognized in the treatment of bone and joint diseases due to its unique advantages of multi-target,multi-pathway,multi-mechanism synergism,low price,and low side effects.With the deepening of research,the targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases has attracted wide attention.In this paper,the mechanism of NLRP3 inflammasome in osteoarthritis was summarized by analyzing relevant literature in China and abroad in recent years,and the progress of targeted intervention of NLRP3 inflammasome by TCM in the treatment of bone and joint diseases was systematically reviewed,so as to provide new ideas and theoretical basis for the treatment of bone and joint diseases.

关 键 词：核苷酸结合寡聚化结构域样受体蛋白3(NLRP3) 炎症小体 骨与关节疾病 中医药 机制 

分 类 号：R284.2[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24