急诊床边血液灌流治疗急性药物及农药中毒患者的疗效及安全性评价  

Efficacy and safety evaluation of emergency bedside hemoperfusion in patients with acute drug and pesticide poisoning

作　　者：杨斌 Yang Bin(The people's hospital of Guangchang County,Guangchang,Jiangxi 344900)

机构地区：[1]广昌县人民医院,江西广昌344900

出　　处：《基层医学论坛》2023年第22期40-42,共3页The Medical Forum

摘　　要：目的探究急诊床边血液灌流治疗急性药物及农药中毒患者的疗效及安全性。方法回顾性分析2019年2月—2021年11月广昌县人民医院收治的72例急性药物及农药中毒患者的临床资料,依据治疗方法不同分为研究组(行血液灌流)36例及对照组(行常规治疗)36例。对比2组肝肾功能[天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBIL)、血尿素氮(BUN)、血肌酐(SCR)]、凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)]、血常规及电解质各指标水平变化[白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)、钠离子(Na^(+))、钾离子(K^(+))、氯离子(Cl^(-))、钙离子(Ca^(2+))]。结果治疗后研究组ALT、AST、TBIL、BUN及SCR水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后研究组PT、APTT、TT均短于对照组,FIB水平高于对照组,差异均有统计学意义(P<0.05)。治疗后2组WBC、RBC、Hb、Na^(+)、K^(+)、Cl^(-)、Ca^(2+)水平比较,差异均无统计学意义(P>0.05)。结论急诊床边血液灌流在急性药物及农药中毒患者治疗中具有较好效果,有助于改善患者肝肾功能及凝血功能,不会对电解质水平造成影响,值得推广。Objective To explore the efficacy and safety of emergency bedside hemoperfusion in the treatment of acute drug and pesticide poisoning patients.Methods A retrospective analysis was made of 72 patients with acute drug and pesticide poisoning admitted to our hospital from February 2019 to November 2021.According to different treatment methods,they were divided into a study group(with blood perfusion)of 36 cases and a control group(with conventional treatment)of 36 cases.Comparison of liver and kidney functions[aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin,blood urea nitrogen(BUN),serum creatinine(Scr)],coagulation function indexes[coagulation Proenzyme time(PT),activated partial thrombin time(APTT),thrombin time(TT),fibrinogen(FIB)],changes in blood routine and electrolyte levels[white blood cells(WBC),red blood cells(RBC),Hemoglobin(Hb),sodium ion(Na^(+)),potassium ion(K^(+)),chloride ion(Cl^(-)),calcium ion(Ca^(2+))].Results The levels of ALT,AST,total bilirubin,BUN and Scr in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The PT,APTT and TT of the study group were faster than those of the control group,and the level of FIB was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the levels of WBC,RBC,Hb,Na^(+),K^(+),Cl^(-),and Ca^(2+)between the two groups(P>0.05).Conclusion Emergency bedside hemoperfusion has achieved good results in the treatment of acute drug and pesticide poisoning patients.

关 键 词：急性药物 农药中毒 急诊床边血液灌流 疗效 安全性 

分 类 号：R595.4[医药卫生—内科学]