比索洛尔和地尔硫?治疗老年单纯性收缩期高血压的有效性和安全性比较  

Comparison of the efficacy and safety of bisoprolol and diltiazem in the treatment of elderly isolated systolic hypertension

作　　者：李静宇 柏凡 赵振 杨征[2] LI Jingyu;BAI Fan;ZHAO Zhen;YANG Zheng(the People's Hospital of Nanzheng District,Hanzhong 723100;Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]南郑区人民医院,陕西汉中723100 [2]陕西省人民医院,陕西西安710068

出　　处：《临床医学研究与实践》2023年第25期62-65,共4页Clinical Research and Practice

摘　　要：目的比较比索洛尔和地尔硫治疗老年单纯性收缩期高血压的有效性和安全性。方法选取2018年1月至2021年1月就诊的90例老年单纯性收缩期高血压患者,采用随机数字表法将其分为比索洛尔组(45例,比索洛尔治疗)和地尔硫组(45例,地尔硫治疗)。比较两组的治疗效果。结果治疗后,地尔硫组的收缩压(SBP)、心率低于比索洛尔组,差异具有统计学意义(P<0.05);治疗后,两组的舒张压(DBP)比较,差异无统计学意义(P>0.05)。地尔硫组的治疗总有效率高于比索洛尔组,差异具有统计学意义(P<0.05)。治疗后1周,两组的超敏C反应蛋白(hs-CRP)、细胞间黏附因子-1(ICAM-1)和可溶性P-选择素(sP-sel)水平低于治疗前,且比索洛尔组低于地尔硫组,差异具有统计学意义(P<0.05)。地尔硫组的不良反应总发生率低于比索洛尔组,差异具有统计学意义(P<0.05)。结论地尔硫在改善老年单纯性收缩期高血压患者SBP、心率等方面效果更佳,不良反应发生率更低,但比索洛尔在抑制炎性反应方面更佳,因此临床需结合实际情况进行方案选取。Objective To compare the efficacy and safety of bisoprolol and diltiazem in the treatment of elderly isolated systolic hypertension.Methods A total of 90 elderly patients with isolated systolic hypertension who were admitted from January 2018 to January 2021 were selected and divided into bisoprolol group(45 cases,bisoprolol treatment)and diltiazem group(45 cases,diltiazem treatment)by random number table method.The therapeutic effects of the two groups were compared.Results After treatment,the systolic blood pressure(SBP)and heart rate in the diltiazem group were lower than those in the bisoprolol group,and the differences were statistically significant(P<0.05);after treatment,there was no significant difference in diastolic blood pressure(DBP)between the two groups(P>0.05).The total effective rate of treatment in the diltiazem group was higher than that in the bisoprolol group,and the difference was statistically significant(P<0.05).One week after treatment,the levels of high sensitive C-reactive protein(hs-CRP),intercellular adhesion molecule-1(ICAM-1)and soluble P-selectin(sP-sel)in the two groups were lower than those before treatment,and those in the bisoprolol group were lower than the diltiazem group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the diltiazem group was lower than that in the bisoprolol group,and the difference was statistically significant(P<0.05).Conclusion Diltiazem is more effective in improving SBP and heart rate in elderly isolated systolic hypertension,and has lower incidence of adverse reactions,but bisoprolol is better in inhibiting inflammatory reaction.Therefore,it needs to be selected based on actual situations for clinical plans.

关 键 词：老年 单纯性收缩期高血压 比索洛尔 地尔硫? 

分 类 号：R544.1[医药卫生—心血管疾病]