人类免疫缺陷病毒感染者合并乙肝感染现状及影响因素分析  

Analysis of the Status Quo and Influencing Factors of Hepatitis B Infection in HIV-Infected

作　　者：陈雪玲 王莎莎 CHEN Xueling;WANG Shasha(Department of Disease Prevention and Control,Quanzhou First Hospital,Quanzhou Fujian 362000,China)

机构地区：[1]泉州市第一医院疾病预防控制科,福建泉州362000

出　　处：《中国卫生标准管理》2023年第15期39-43,共5页China Health Standard Management

摘　　要：目的探讨人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者合并乙型肝炎病毒(hepatitis B virus,HBV)感染的现状,分析此类人群合并HBV感染的影响因素。方法对HIV感染者进行选取(选取时间:2021年1月—2022年12月,选取地点:泉州地区,选取例数:516例),并以面对面问卷方式对其一般人口学特征(职业、婚姻状况、年龄、文化程度、性别等)及可能与合并HBV感染相关的因素(如乙肝疫苗接种史、性伴不固定、性病史、性行为、吸毒史等)进行调查。对研究对象的血液标本进行采集,并开展乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)检测。采用SAS统计学软件开展统计分析,并以非条件Logistic回归分析法,对HIV/HBV合并感染的影响因素加以明确。结果在516例HIV感染者中,检出合并HBV感染113例,检出率为21.90%;经多因素Logistic回归分析得知,HIV感染者合并HBV的主要危险因素有25~45岁、无乙型肝炎疫苗接种史、有性病史。结论针对HIV感染者,其在合并HBV感染上有着较高的检出率,25~45岁、有性病史与无乙型肝炎疫苗接种史是HIV感染者发生HBV感染的常见风险因素,建议HIV感染者强化对HBV感染的监测工作,有效控制合并感染的发生。Objective To explore the current situation of human immunodeficiency virus(HIV)infected people with hepatitis B virus(HBV)infection,and analyze the influencing factors of such people with HBV infection.Methods HIV-infected people were selected(selection time:January 2021 to December 2022,selection location:Quanzhou area,number of selected cases:516 cases),and their general demography characteristics(occupation,marital status,age,education level,ethnic group,gender,etc.)and possible factors related to combined HBV infection(such as hepatitis B vaccination history,HIV infection route,irregular sexual partners,history of sexually transmitted diseases,sexual behavior,drug abuse history,etc.)were investigated by face-to-face questionnaire.Blood samples of the subjects were collected,and hepatitis B surface antigen(HBsAg)was detected.SAS statistical analysis was conducted using statistical software,and the influencing factors of HIV/HBV co infection were identified using unconditional Logistic regression analysis.Results Out of 516 HIV infected individuals,113 were found to be co infected with HBV,with a detection rate of 21.90%.Through multivariate Logistic regression analysis,it was found that the main risk factors for HIV infected individuals merging with HBV include 25-45 years old,no history of hepatitis B vaccination,and having a history of sexual illness.Conclusion For HIV infected individuals,there is a high detection rate for co infection with HBV.25-45 years old,having a history of sexual illness,and no history of hepatitis B vaccination are common risk factors for HIV infected individuals to develop HBV infection.It is recommended that HIV infected individuals strengthen monitoring of HBV infection and effectively control the occurrence of co infection.

关 键 词：人类免疫缺陷病毒 乙型肝炎病毒 影响因素 合并感染 年龄 疫苗接种史 

分 类 号：R512[医药卫生—内科学]