高纯度3′,3′′,4′′,5′′-四氟-4-丙基对三联苯的制备方法  

Preparation of High-purity 3′,3′′,4′′,5′′-Tetrafluoro-4-propyl-triphenyl

作　　者：张力 岳刚 丁秋月 王利民 禹凯 关登仕 刘宝友[2] ZHANG Li;YUE Gang;DING Qiu-yue;WANG Li-min;YU Kai;GUAN Deng-shi;LIU Bao-you(Hebei Maison Chemical Co.,Ltd.,Xinji 052360,China;Hebei University of Science and Technology,Shijiazhuang 050018,China)

机构地区：[1]河北美星化工有限公司,河北辛集052360 [2]河北科技大学,河北石家庄050018

出　　处：《精细化工中间体》2023年第3期58-61,共4页Fine Chemical Intermediates

基　　金：辛集市科技计划项目(202119)。

摘　　要：以2,3′,4′,5′-四氟-4-溴联苯和4-丙基苯硼酸为原料,通过铃木偶联反应合成3′,3′′,4′′,5′′-四氟-4-丙基对三联苯,优化条件下纯度99.992%(GC),收率92.3%,目标化合物结构经^(1)H NMR表征确证。工艺以咪唑类离子液体为溶剂,降低了2,3′,4′,5′-四氟-4-溴联苯自偶联产物和脱氟产物的生成,溶剂用量减少,工艺简化且绿色环保,适合工业化生产。An efficient way for the synthesis of 3′,3′′,4′′,5′′-tetrafluoro-4-propyl-triphenyl by using 2,3′,4′,5′-tetrafluoro-4-bromobiphenyl and 4-propyl phenylboronic acid as raw materials through Suzuki coupling reaction has been designed,moreover,the advantages for using imidazoles ionic liquids in the synthetic method were de-scribed,a purity of 99.992%(GC)and a yield of 92.3%was achieved for the target product.The structure of the target compound was characterized by^(1)H NMR.Using imidazole ionic liquid as solvent was the breakthrough points in this preparation process including effectively reducing the 2,3′,4′,5′-tetrafluoride-4-bromobiphenyl self-coupling products,and the generation of defluorinated products,effectively reducing the conventional sol-vent dosage,the green environmental protection and simplified process,and suitable for industrial production.

关 键 词：铃木偶联 离子液体 绿色环保 

分 类 号：O625[理学—有机化学]