镁离子治疗射血分数保留性心力衰竭的效果研究  

Effectiveness of magnesium ion in the treatment of heart failure with preserved ejection fraction

作　　者：林绍怡 张光平 李锦良 程卓 贺正波 沈铭 Lin Shaoyi;Zhang Guangping;Li Jinliang;Cheng Zhuo;He Zhengbo;Shen Ming(Department of Critical Emergency,Third Affiliated Hospital of Guangdong Medical University,Foshan Guangdong528318,China)

机构地区：[1]广东医科大学附属第三医院重症急救医学部,广东佛山528318

出　　处：《中国药物与临床》2023年第2期86-90,共5页Chinese Remedies & Clinics

基　　金：广东省佛山市自筹经费类科技计划项目(2020001005496)。

摘　　要：目的探讨镁离子治疗射血分数保留性心力衰竭(HFpEF)的临床效果。方法将2021年2月至2022年2月广东医科大学附属第三医院心血管内科收治的106例HFpEF患者纳入研究,按随机数字表法分为试验组与对照组(各53例),对照组给予常规抗心力衰竭药物治疗,试验组在对照组基础上将常规极化液更换为“镁极化液”治疗,比较2组肾功能、N末端脑利钠肽前体(NT-proBNP)值、左心室射血分数(LVEF)、6 min步行距离、心功能分级、左心室舒张功能。结果2组性别、年龄、病程及纽约心脏协会(NYHA)分级比较差异无统计学意义(P>0.05);试验组总有效率(94%)高于对照组(81%)(P<0.05);2组治疗前后肾功能指标肌酐(SCr)、胱抑素C(CysC)、24 h尿量比较差异无统计学意义(P>0.05);2组治疗前LVEF、NT-proBNP水平、6 min步行距离比较差异无统计学意义(P>0.05),2组治疗后LVEF、6 min步行距离高于治疗前,试验组高于对照组(P<0.05),2组治疗后NT-proBNP低于治疗前,试验组低于对照组(P<0.05);试验组治疗后NYHA分级情况优于对照组(P<0.05);治疗前,2组左房室容积(LAVI)、左心室质量指数(LVMI)、室间隔e′速度、侧壁e′速度、三尖瓣最大反流速度、E/e′差异无统计学意义(P>0.05),治疗后,2组LAVI、LVMI、三尖瓣最大反流速度、E/e′低于治疗前,试验组低于对照组(P<0.05),2组治疗后室间隔e′速度、侧壁e′速度高于治疗前,试验组高于对照组(P<0.05)。结论镁离子治疗HFpEF可有效调节患者LVEF指标与NT-proBNP水平,改善心功能分级与心力衰竭症状,还可明显调节其左心室舒张功能,且对肾功能无明显影响。Objective To investigate the clinical effect of magnesium ion in the treatment of heart failure with preserved ejection fraction(HFpEF).Methods From February 2021 to February 2022,a total of 106 pa-tients with HFpEF who were admitted to the Department of Cardiovascular Medicine,the third affiliated hospital of Guangdong Medical University were included in the study,and were divided into an experimental group and a control group(53 cases in each)according to the random number table method.The control group was given con-ventional anti-heart failure drug treatment,and the experimental group was given“magnesium polarized liquid”on the basis of the control group.Renal function,N-terminal brain natriuretic peptide precursor(NT-proBNP),left ventricular ejection fraction(LVEF),6 min walking distance,cardiac function classification,left ventricular dias-tolic function,were compared between the two groups.Results There was no significant difference in sex,mean age,mean course of disease and NYHA classification between the two groups(P>0.05);the total effective rate of the experimental group(94%)was higher than that of the control group(81%)(P<0.05).There was no significant difference in renal function indexes SCr,CysC,and 24h urine volume between the two groups before and after treatment(P>0.05).There was no significant difference in LVRF,NT-proBNP levels,and 6 min walking distance between the two groups before treatment(P>0.05),LVEF and 6 min walking distance in the two groups after treat-ment were higher than those before treatment,and the experimental group was higher than that in the control group(P<0.05).The NYHA classification of the experimental group after treatment was significantly better than that of the control group(P<0.05).There was no significant difference in velocity,E/e′,ratio(P>0.05).After treat-ment,the LAVI,LVMI,tricuspid regurgitation velocity,E/e′,ratio of the two groups were lower than those before treatment,and the experimental group was lower than the control group(P<0.05),ventricular sep

关 键 词：心力衰竭 心功能试验 镁缺乏 心室功能 左 

分 类 号：R541.6[医药卫生—心血管疾病]