血清PAPP-A、CA125在先兆流产保胎治疗孕妇难免流产中的预测价值  

Value of serum PAPP-A and CA125 in prediction of inevitable abortion of pregnant women with threatened abortion undergoing tocolytic therapy

作　　者：宋晓艳 SONG Xiaoyan(Department of Obstetrics and Gynecology of Luoyang Yiluo Hospital,Luoyang 471000 Henan,China)

机构地区：[1]洛阳伊洛医院妇产科,河南洛阳471000

出　　处：《中国民康医学》2023年第15期134-136,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清妊娠相关血浆蛋白A(PAPP-A)、糖类抗原125(CA125)在先兆流产保胎治疗孕妇难免流产中的预测价值。方法:选取2018年12月至2022年12月该院收治的65例先兆流产孕妇为研究对象,纳入研究组,另选取65名同期于该院行常规孕检的健康产妇为对照组。两组均检测血清PAPP-A、CA125水平,并对先兆流产保胎治疗孕妇进行随访,根据是否发生难免流产,将其分为保胎成功组和难免流产组。采用受试者工作特征曲线(ROC)分析血清PAPP-A、CA125在先兆流产保胎治疗孕妇难免流产中的预测价值。结果:65例先兆流产保胎治疗孕妇中难免流产13例,占20.00%(13/65);研究组血清PAPP-A水平低于对照组,CA125水平高于对照组,差异有统计学意义(P<0.05);难免流产组血清PAPP-A水平低于保胎成功组,CA125水平高于保胎成功组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清PAPP-A、CA125联合检测预测先兆流产保胎治疗孕妇难免流产的曲线下面积>0.7,有一定预测价值,且高于各单项检测。结论:血清PAPP-A、CA125联合检测在先兆流产保胎治疗孕妇难免流产中的预测价值高于各单项检测。Objective:To analyze value of serum pregnancy-associated plasma protein A(PAPP-A)and carbohydrate antigen 125(CA125)in prediction of inevitable abortion of pregnant women with threatened abortion undergoing tocolytic therapy.Methods:65 pregnant women with threatened abortion admitted to the hospital from December 2018 to December 2022 were selected as the research objects and included in study group.In addition,65 healthy pregnant women who underwent routine pregnancy examination in the hospital during the same period were selected as control group.The serum PAPP-A and CA125 levels were detected in both groups and the pregnant women with threatened abortion undergoing tocolytic therapy were followed up.According to whether inevitable abortion occurred,they were divided into successful fetus protection group and inevitable abortion group.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of serum PAPP-A and CA125 in the inevitable abortion of the pregnant women with threatened abortion undergoing tocolytic therapy.Results:There were 13 cases of inevitable abortion in the 65 pregnant women with threatened abortion undergoing tocolytic therapy,accounting for 20.00%(13/65).The serum PAPP-A level in the study group was lower than that in the control group,the serum CA125 level was higher than that in the control group,and the differences were statistically significant(P<0.05).The serum PAPP-A level in the inevitable abortion group was lower than that in the successful fetus protection group,the serum CA125 level was higher than that in the successful fetus protection group,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the AUC of combined detection of serum PAPP-A and CA125 in the prediction of inevitable abortion of the pregnant women with threatened abortion undergoing tocolytic therapy was>0.7,which had certain predictive value and was higher than that of each single detection.Conclusions:The value of combined detection of serum PA

关 键 词：先兆流产 难免流产 妊娠相关血浆蛋白A 糖类抗原125 预测 效能 

分 类 号：R714.21[医药卫生—妇产科学]