乙肝免疫学标志物定量、血清HBV-DNA载量和老年慢性乙肝病人肝功能的关系研究  

Relationship Study between Liver Function,Quantity of Immunological Markers of Hepatitis B,Serum HBV Load of Elderly Patients with Chronic Hepatitis B

作　　者：张笑言 ZHANG Xiaoyan(Baicheng Central Hospital,Baicheng,Jilin 137000)

机构地区：[1]白城中心医院,吉林白城137000

出　　处：《智慧健康》2023年第16期121-124,共4页Smart Healthcare

摘　　要：目的探讨乙肝免疫学标志物(HBV-M)定量、血清乙肝病毒(HBV-DNA)载量与老年慢性乙肝病人肝功能的关系。方法对2021年4月-2022年9月收治的90名慢性乙肝老年病人通过荧光定量PCR技术定量检测HBV-DNA含量,通过酶联免疫吸附试验(ELISA)检测HBV-M定量,即检测病人肝功能谷丙转氨酶(ALT)、前白蛋白(PA)以及谷草转氨酶(AST)水平。结果大三阳组HBV-DNA定量值平均为(64568.45±4329.52)copy/mL,小三阳组为(20230.23±3419.19)copy/mL,HBcAg+HBcAb阳性组为(15673.54±2108.98)copy/mL,大三阳组的HBV-DNA定量明显高于小三阳组和HBcAg+HBcAb阳性组,对比具备统计学意义(P<0.05);而小三阳组和HBcAg+HBcAb阳性组对比区别不明显,无统计学意义(P>0.05)。三组ALT、PA、AST水平对比中,ALT和AST水平大三阳组、小三阳组及HBcAg+HBcAb阳性组从高到低,而PA水平则由低到高,对比具备统计学意义(P<0.05)。HBV-DNA定量值和年龄存在一定的关系,以65~70岁病人最高。结论慢性乙肝病人HBV-M定量和HBV-DNA载量与病人肝功能之间有着密切关系,对各项指标进行全面检测有助于老年慢性乙肝病人病情的筛查、检测、诊断以及治疗等。Objective To explore relationship between quantity of hepatitis B immunological marker(HBV-M),serum hepatitis B virus(HBV-DNA)load and liver function of elderly patients with chronic hepatitis B.Methods The paper chose 90 elderly patients with chronic hepatitis B from April 2021 to September 2022,detected HBV DNA content with fluorescent quantitative PCR technology,HBV M content with enzyme-linked immunosorbent assay(ELISA),including levels of alanine transaminase(ALT),prealbumin(PA)and aspartate transaminase(AST)of liver function of patients.Results Average quantitative value of HBV DNA in large three positive group was(64568.45±4329.52)copy/mL,while that in small three positive group was(20230.23±3419.19)copy/mL and that in HBcAg+HBcAb positive group was(15673.54±2108.98)copy/mL.Quantitative value of HBV DNA in large three positive group was significantly higher than small three positive group and HBcAg+HBcAb positive group,comparison was statistically significant(P<0.05).However,there was no significant difference between small three positive group and HBcAg+HBcAb positive group,there was no statistical significance(P>0.05).Comparison of ALT,PA and AST levels among three groups showed,ALT and AST levels in large three positive group,small three positive group and HBcAg+HBcAb positive group increased from high to low,while PA level increased from low to high,indicating statistical significance(P<0.05).There was some certain relationship between quantitative value of HBV-DNA and age,with the highest value for patients aged 65-70.Conclusion There is close relationship between quantity of HBV-M and HBV-DNA load of chronic hepatitis B patients and liver function of patients.Comprehensive detection of various indicators is helpful to screening,detection,diagnosis and treatment of elderly patients with chronic hepatitis B.

关 键 词：乙肝免疫学标志物定量 血清HBV-DNA载量 老年慢性乙肝 肝功能 

分 类 号：R512.62[医药卫生—内科学]