血清TIMP-2、PLGF与高龄子痫前期患者胎儿生长受限的关系  

Relations hip between serum tissue inhibitor of matrix metalloproteinase,placental growth factor and fetal growth restriction in elderly patients with preeelampsia

作　　者：孔琼 牛瑶[1] 桑国耀[1] KONG Qiong;NIU Yao;SANG Guoyao(Medical Laboratory Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院医学检验中心,乌鲁木齐830000

出　　处：《中国性科学》2023年第8期32-35,共4页Chinese Journal of Human Sexuality

基　　金：新疆维吾尔自治区自然科学基金(2018D01C184)。

摘　　要：目的 分析血清基质金属蛋白酶抑制因子(TIMP)-2、胎盘生长因子(PLGF)与高龄子痫前期(PE)患者发生胎儿生长受限(FGR)的关系。方法 采用前瞻性队列研究法选取2020年3月至2022年2月于新疆医科大学第一附属医院产检的138例高龄PE患者作为研究对象,纳入PE组;另选取同期在同一医院接受产检的138例高龄孕妇作为对照组。检查所有研究对象的肝肾功能[血肌酐(Scr)、谷丙转氨酶(ALT)、谷草转氨酶(AST)]、孕激素及血清TIMP-2、PLGF等。统计患者FGR发生情况,并分为FGR组和N-FGR组,采用Logistic回归分析血清TIMP-2、PLGF与高龄PE患者发生FGR的关系。结果 PE组血清TIMP-2水平高于对照组,血清PLGF水平低于对照组,差异均具有统计学意义(P<0.05)。138例高龄PE患者发生流产8例,胎停3例,退出研究2例,最终125例患者获得随访结果,胎儿娩出时确诊为FGR 27例。FGR组收缩压(SBP)、舒张压(DBP)、Scr及血清ALT、AST、TIMP-2水平均高于N-FGR组,血清PLGF水平低于N-FGR组,差异均具有统计学意义(P<0.05)。Logistic回归分析结果显示,血清TIMP-2高表达、PLGF低表达与高龄PE孕妇发生FGR有关(P<0.05)。结论 FGR患者血清TIMP-2显著升高,而PLGF水平显著降低;血清TIMP-2高表达、PLGF低表达是导致高龄PE孕妇FGR风险增加的危险因素。Objective To analyze relationship between tissue inhibitor of matrix metalloproteinase(TIMP)-2,placental growth factor(PLGF)and fetal growth restriction(FGR)in elderly patients with preeclampsia(PE).Methods Method of prospective cohort study was used,138 elderly pregnant women diagnosed with PE who underwent antenatal care in the First Affiliated Hospital of Xinjiang Medical University between March 2020 and February 2022 were selected as subjects and included in the PE group.In addition,138 elderly pregnant women who received antenatal care in the same hospital during same period were included as control group.Examination items included liver and kidney function[serum creatinine(Scr),alanine aminotransferase(ALT),aspartate aminotransferase(AST)],progesterone and serum TIMP-2,PLGF,etc.Incidence of FGR in patients during follow-up was statistically analyzed,and patients were divided into FGR group and N-FGR group,Logistic regression were used to analyze relationship between serum TIMP-2 and PLGF and FGR in elderly PE patients.Results The serum TIMP-2 level of PE group was higher than control group,and serum PLGF level was lower than control group,the difference was statistically significant(P<0.05).Among 138 elderly PE patients,8 had abortion,3 had fetal arrest,and 2 had dropped out of the study.Final follow-up results were obtained in 125 patients,and 27 cases were diagnosed with FGR at the time of delivery.Levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),Scr,and serum ALT,AST,and TIMP-2 in FGR group were higher than N-FGR group,and level of serum PLGF was lower than N-FGR group,with a statistically significant differences(P<0.05).Logistic regression analysis showed that high expression of serum TIMP-2 and low expression of PLGF were related to FGR in elderly PE pregnant women(P<0.05).Conclusions Serum TIMP-2 was significantly increased in FGR patients,while the level of PLGF was significantly decreased.High expression of serum TIMP-2 and low expression of PLGF were risk factors leading to inc

关 键 词：高龄孕妇 子痫前期 胎儿生长受限 基质金属蛋白酶抑制因子-2 胎盘生长因子 

分 类 号：R714[医药卫生—妇产科学]