基于氧化应激及血清TGF-β1、MCP-1、HO-1水平变化探讨高压氧联合头孢羟氨苄治疗慢性盆腔炎的效果  

Effect of hyperbaric oxygen combined with cefadroxil on chronie pelvic inflammatory disease based on oxidative stress and changes in serum transforming growth factor-pl,monocyte chemoattractant protein-1 and heme oxygen-1 levels

作　　者：孙红玲 桂定清 张力忆[1] 刘芳[1] SUN Honging;GUI Dingqing;ZHANG Liyi;LIU Fang(Department of Obstetrics and Gynecology,Dazhou Central Hospital,Dazhou 635000,Sichuan,China)

机构地区：[1]达州市中心医院妇产科,四川达州635000

出　　处：《中国性科学》2023年第8期36-39,共4页Chinese Journal of Human Sexuality

基　　金：四川省卫生健康科研课题资助项目(19PJ274)。

摘　　要：目的 探究高压氧联合头孢羟氨苄治疗慢性盆腔炎(CPID)的效果及对氧化应激、血清转化生长因子-β1(TGF-β1)、单核细胞趋化蛋白-1(MCP-1)、血红素氧和酶-1(HO-1)水平的影响。方法 选取2019年10月至2021年3月达州市中心医院收治的124例CPID患者作为研究对象,按照随机数字表法分为观察组(n=62)、对照组(n=62)。对照组给予头孢羟氨苄治疗,观察组给予高压氧联合头孢羟氨苄治疗。比较两组疗效、治疗前后症状评分、炎症因子水平、氧化应激、不良反应发生率、复发率。结果 观察组总有效率93.55%较对照组的80.65%高(P<0.05);治疗后观察组症状评分、MCP-1、HO-1、活性氧(ROS)、丙二醛(MDA)较对照组低,TGF-β1、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平较对照组高(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);随访3个月,观察组复发率较对照组低(P<0.05)。结论 高压氧联合头孢羟氨苄治疗CPID患者效果显著,可有效促使症状改善,减轻机体炎症、氧化应激,降低复发风险,安全性较高。Objective To explore the effect of hyperbaric oxygen combined with cefadroxil in the treatment of chronic pelvic inflammatory disease(CPID)and the effects on oxidative stress,serum transforming growth factor-β1(TGF-β1),monocyte chemoattractant protein-1(MCP-1),heme oxygen-1(HO-1)levels.Methods A total of 124 CPID patients admitted to Dazhou Central Hospital from October 2019 to March 2021 were selected as the research objects.According to the random number table method,they were divided into an observation group and a control group,with 62 cases in each group.The control group was treated with cefadroxil,and the observation group was treated with hyperbaric oxygen combined with cefadroxil.The curative effect,the symptom score before and after treatment,the level of inflammatory factors,oxidative stress indicators and the incidence of adverse reactions and recurrence rates were compared between the two groups.Results The total effective rate of the observation group was 93.55%higher than that of the control group 80.65%(P<0.05).After treatment,the symptom score,the levels of MCP-1,HO-1,reactive oxygen species(ROS),and malondialdehyde(MDA)in the observation group were lower than those in the control group,and the levels of TGF-β1,superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 3 months of follow-up,the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusions Hyperbaric oxygen combined with cefadroxil has a significant effect in the treatment of CPID patients,which can effectively promote the improvement of symptoms,reduce inflammation and oxidative stress,reduce the risk of recurrence,with high safety.

关 键 词：氧化应激 炎症 高压氧 头孢羟氨苄 慢性盆腔炎 

分 类 号：R711[医药卫生—妇产科学]