男性尖锐湿疣临床治愈后人乳头瘤病毒持续感染的危险因素分析  

Analysis of riskfactors for persistent infection of human papilloma virusafter the clinical cure of male condyloma acuminatum

作　　者：李水凤 李丽雅 邝绍明 张青[4] 杜健群 胡荣欣 李英[1] 王军雄 卢斯汉 LI Shuifeng;LI Liya;KUANG Shaoming;ZHANG Qing;DU Jianqun;HU Rongxin;LIYing;WANG Junxiong;LU Sihan(Department of Dermatology and Venereal Disease,Guangzhou Eighth People′sHospital,Guangzhou Medical University,Guangzhou510060,Guangdong,China;Department of Research,Guangzhou EighthPeople′s Hospital,Guangzhou Medical University,Guangzhou 510060,Guangdong,China;Department of Laboratory Medicine,Guangzhou Eighth People′s Hospital,Guangzhou Medical University,Guangzhou 510060,Guangdong,China;Department of Hospital Infection-Control,Guangzhou Eighth People′s Hospital,Guangzhou Medical University,Guangzhou 510060,Guangdong,China)

机构地区：[1]广州医科大学附属市八医院皮肤性病科,广州510060 [2]广州医科大学附属市八医院研究所,广州510060 [3]广州医科大学附属市八医院检验科,广州510060 [4]广州医科大学附属市八医院院感科,广州510060

出　　处：《中国性科学》2023年第8期136-140,共5页Chinese Journal of Human Sexuality

基　　金：广州市卫生健康科技项目(20221A011040)。

摘　　要：目的 观察男性尖锐湿疣(CA)患者临床治愈后人乳头瘤病毒(HPV)持续感染的危险因素。方法 回顾性分析2015年1月至2021年6月广州医科大学附属市八医院诊治的332例男性CA患者治疗前后的HPV分型检测结果,统计CA临床治愈后HPV的持续感染率并分析其危险因素。结果 332例男性CA患者治疗前HPV检测均阳性,CA临床治愈后HPV持续感染140例(42.17%)。皮损位置(肛门)、治疗前HPV型别数(≥2)是HPV持续感染的危险因素(P<0.001)。HPV持续感染与年龄、是否伴发人类免疫缺陷病毒(HIV)、治疗前是否含高危型HPV感染、是否联合光动力治疗及随访时间均无相关性(P>0.05)。结论 男性肛门CA患者、多重HPV感染CA患者临床治愈后HPV持续感染风险高,建议延长随访时间,甚至终生随访。Objective To observe the risk factors of persistent infection of human papilloma virus(HPV)in male patients with condyloma acuminatum(CA)after clinic cure.Methods The results of HPV typing test before and after treatment among 332 male patients with CA treated in Guangzhou Eighth People′s Hospital,Guangzhou Medical University from January 2015 to June 2021 were retrospective analysed.The persistent infection rate of HPV after clinical cure in CA were recorded,and its risk factors were explored.Results The results of HPV type of 332 male patients with CA were all positive before treatment.After treatment,140 of them continued to be infected with HPV,the HPV persistent rate was 42.17%.CA site(anal CA)and HPV types(≥2)before treament were the risk factors for HPV persistent infection(P<0.001).There was no correlation between HPV persistent rate and age,coinfection with HIV,high risk type of HPV before treatment,treatment modality combined with photodynamic therapy,follow-up time(P>0.05).Conclusions For male patients with CA,anal CA and CA caused by more than 2 types of HPV have the higher risk of persistent HPV infection after clinical treatment.For these patients,it is recommended to extend the follow-up time,even for a lifetime.

关 键 词：尖锐湿疣 人乳头瘤病毒 人类免疫缺陷病毒 光动力 

分 类 号：R759[医药卫生—皮肤病学与性病学]