miRNA对2型糖尿病合并慢性心力衰竭心室重构的影响研究概况  

The effect of miRNA on ventricular remodeling in type 2 diabetes patients with chronic heart failure

作　　者：张毅 张军[2] 刘学文 崔文硕 ZHANG Yi

机构地区：[1]华北理工大学,河北唐山063000 [2]唐山市中医医院,河北唐山063000

出　　处：《中医临床研究》2023年第23期69-74,共6页Clinical Journal Of Chinese Medicine

摘　　要：小分子核糖核酸(microRNA,miRNA)是RNA里的一个小片段,长度约22个核苷酸。它可以精确调节编码蛋白质基因的激活,还能够压制它们的目标,从而协调复杂的遗传程序。miRNA参与众多疾病的发病过程。近年来,大量试验及研究表明,miRNA参与了心脏重塑的病理过程。在心肌肥厚、心肌纤维化以及心肌细胞凋亡的发生、发展过程中,miRNA均起到了重要的调控作用,且miRNA对于转化生长因子-β(Transforming Growth Factor-β,TGF-β)具有一定的调控作用。糖尿病可以引发神经、组织及器官的病变,其中心血管疾病是2型糖尿病最常见的并发症之一,也是导致糖尿病患者死亡的最主要原因,2型糖尿病是心力衰竭发生、发展过程中一个重要的危险因素。研究通过查阅近年来有关miRNA对2型糖尿病合并慢性心力衰竭心室重构的中外医学文献,分析各类型的miRNA与心肌肥厚、心肌纤维化以及心肌细胞凋亡之间的关系,为深入了解该病的病理机制、进一步临床研究提供依据。Micro ribonucleic acids(miRNA)are small fragments in RNA,about 22 nucleotides in length.It can precisely regulate the activation of protein coding genes.miRNA can also suppress their goals,thereby coordinating complex genetic programs.miRNA are involved in the pathogenesis of many diseases.In recent years,a large number of experiments and studies have shown that miRNA participate in the pathological process of cardiac remodeling.miRNA play an important role in the occurrence and development of myocardial hypertrophy,myocardial fibrosis and cardiomyocyte apoptosis,and miRNA has a certain regulatory effect on TGF-β.Diabetes can cause nerve,tissue and organ lesions,of which cardiovascular disease is one of the most common complications of type 2 diabetes,but also the most important cause of death in diabetic patients,type 2 diabetes is an important risk factor in the occurrence and development of heart failure.In this paper,we reviewed the recent domestic and foreign medical literature on miRNA for ventricular remodeling in type 2 diabetes patients with chronic heart failure,and analyzed the relationship between various types of miRNA and myocardial hypertrophy,myocardial fibrosis,and cardiomyocyte apoptosis,so as to provide a basis for further understanding of the pathological mechanism of the disease and further clinical research.

关 键 词：心室重构 研究概况 小分子核糖核酸 核糖核酸 2型糖尿病 

分 类 号：R541.6[医药卫生—心血管疾病]