Wnt信号通路与阿尔茨海默病的相关性及靶点研究  

Correlation Between Wnt Signaling Pathway and Alzheimer's Disease and Its Targets

作　　者：郭宝 刘子铭 景永帅[1] 张丹参[1] GUO Bao;LIU Zi-ming;JING Yong-shuai;ZHANG Dan-shen(College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang,050018,China)

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018

出　　处：《神经药理学报》2023年第1期56-64,共9页Acta Neuropharmacologica

基　　金：河北省重点研发计划项目生物医药专项项目(No.20372509D);河北省自然科学基金项目(No.H2020208032)。

摘　　要：阿尔茨海默病(Alzheimer’s disease, AD)是一种与衰老相关的神经系统疾病,其病理学特征为细胞外淀粉样β蛋白(amyloid β protein, Aβ)沉积、tau蛋白过度磷酸化以及突触损伤等。Wnt信号通路是一种重要的信号传导途径,在神经退行性疾病阿尔茨海默病中起着非常重要的作用,由于Wnt信号通路在AD脑内受到多种致病机制的抑制,所以Wnt信号相关通路的激活对于AD的治疗有着很大的帮助。目前也有许多中药单体和合成物通过Wnt通路发挥治疗及预防AD的作用,该文对Wnt信号通路与治疗AD的相关性、潜在的治疗靶点及相关有效药物予以综述。Alzheimer's disease(AD)is a neurological disease related to aging,its pathological characteristics are extracellular amyloidβprotein(Ap)deposition,tau protein hyperphosphorylation and synaptic damage,etc.,the production of AD greatly affects people's lives and brings huge economic burden to people.Wnt signaling pathway is an important signaling pathway,plays a very important role in neurodegenerative disease Alzheimer's disease,because Wnt signaling pathway is inhibited by a variety of pathogenic mechanisms in the AD brain,so the activation of Wnt signal-related pathway is of great help to the treatment of AD.At present,there are also many traditional Chinese medicine monomers and synthetics that play a role in the treatment and prevention of AD through the Wnt pathway,and this article reviews the correlation,potential therapeutic targets and related effective drugs of Wnt signaling pathway and the treatment of AD.

关 键 词：阿尔茨海默病 WNT信号通路 治疗药物 

分 类 号：R964[医药卫生—药理学]