A New Cyclization/Decarboxylation Reaction of Isatins with Acyl Chlorides for the Facile Synthesis of 3-Alkenyl-oxindoles  

作　　者：Lin Chen Zhijun Wu Lin Peng Qilin Wang Xiaoying Xu Lixin Wang 

机构地区：[1]Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China [2]Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu,Sichuan 610041,China [3]University of Chinese Academy of Sciences,Beijing 10039,China

出　　处：《Chinese Journal of Chemistry》2014年第9期844-852,共9页中国化学（英文版）

基　　金：We are grateful for the grants from the National Natural Science Foundation of China(No.21272230);Western Light Talent Culture Project of Chinese Academy of Sciences.

摘　　要：The first cyclization/decarboxylation reaction of isatins with acyl chlorides promoted by 4-dimethylaminopyridine(DMAP)was described and a series of desired 3-alkenyl-oxindoles were obtained in good yields(up to 80%)and E/Z selectivities(up to 6.4/1).This protocol provided a new and feasible access to 3-alkenyl-oxindoles.

关 键 词：cyclization/decarboxylation isatin acyl chloride 3-alkenyl-oxindole 

分 类 号：O62[理学—有机化学]