Copper(Ⅱ)-Catalyzed Synthesis of N-Substituted-3-amino-4- cyano-isoquinoline-1(2H)-ones by the Reaction of N-Substituted-2-iodobenzamides with Malononitrile  

作　　者：Yeye Liu Runsheng Zeng Jie Pan Jianping Zou 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,Jiangsu 215123,China

出　　处：《Chinese Journal of Chemistry》2014年第9期883-888,共6页中国化学（英文版）

基　　金：We thank the National Natural Science Foundation of China(Nos.20772088 and 21172163);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for funding this work.

摘　　要：A novel Cu(OAc)_(2)•H_(2)O catalyzed coupling reaction of N-substituted-2-iodobenzamides with malononitrile to afford N-substituted-3-amino-4-cyano-isoquinoline-1(2H)-ones is described.The reaction proceeded in DMSO at 90℃ for 5 h in nitrogen without external ligands.

关 键 词：N-substituted-3-amino-4-cyano-isoquinoline-1(2H)-ones Cu(OAc)_(2)•H_(2)O N-phenyl-2-iodobenzamide 

分 类 号：O64[理学—物理化学]