Catalyst-Free Reaction in Water: Synthesis of Functionalized Tetrahydroindole Derivatives via Three-Component Domino Reaction  

作　　者：Xian Feng Jianjun Wang Wei Lin Juanjuan Zhang Zhibin Huang Daqing Shi 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,Jiangsu 215123,China

出　　处：《Chinese Journal of Chemistry》2014年第9期889-896,共8页中国化学（英文版）

基　　金：This work was partially supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.10KJA150049);the Natural Science Foundation of Jiangsu Province(BK20131160);the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.11KJB150014);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province(No.KJS1210).

摘　　要：An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst-free conditions,by simply combining a phenylglyoxal monohydrate,an enaminone,and a barbituric acid.The advantages of this method are that it is catalyst free,has an easy workup,provides good yields,and uses water as solvent,which make this procedure facile and practical.

关 键 词：functionalized tetrahydroindole derivatives multi-component reaction CATALYST-FREE aqueous medium green chemistry 

分 类 号：O62[理学—有机化学]