Ring Opening of N-Sulfonyl Aziridines by Amines in Silica-Water  

作　　者：Tiantian Li Xiaosi Ma Junmei Qi Feifei Sun Ning Ma 

机构地区：[1]Department of Chemistry,School of Science,Tianjin University,Tianjin 300072,China [2]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China

出　　处：《Chinese Journal of Chemistry》2014年第11期1135-1142,共8页中国化学（英文版）

基　　金：We appreciate the financial support from the National Natural Science Foundation of China(No.20802049).

摘　　要：Ring opening reactions of N-sulfonyl aziridines by primary and secondary amines in silica gel(SG)-water system were achieved,which provided a mild,practical and environmentally benign method to synthesize mono-and bis-sulfonyl substituted amines.When primary and secondary amines were used in excess,they reacted with N-sulfonyl aziridines smoothly at room temperature,mainly affording 1∶1 ring opening products.Reactions of primary amines with 2 equiv.of aziridines produced 2∶1 ring opening products.Some 1∶1 products can be cyclized with CS2 to synthesize N-sulfonyl cyclothioureas also in water.

关 键 词：AZIRIDINES ring opening AMINES silica gel reactions in water 

分 类 号：O62[理学—有机化学]