Hyperbranched Supramolecular Polymer of Tris(permethyl-β- cyclodextrin)s with Porphyrins: Characterization and Magnetic Resonance Imaging  

作　　者：Mo Sun Hengyi Zhang Xinyue Hu Bowen Liu Yu Liu 

机构地区：[1]Department of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2014年第8期771-776,共6页中国化学（英文版）

基　　金：We thank the 973 Program(No.2011CB932500);the NNSFC(Nos.20932004,21372128 and 91227107)for financial support.

摘　　要：A hyperbranched supramolecular polymer(HSP)is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl-β-cyclodextrin)with Mn^(Ⅲ)-porphyrin bearing poly(ethylene glycol)(PEG)side chains(Mn^(Ⅲ)-TPP),and characterized by UV/vis absorption spectroscopy,isothermal titration calorimetry(ITC),NMR,dynamic light scattering(DLS),atomic force microscopy(AFM)and transmission electron microscopy(TEM),respectively.The presence of permethyl-β-cyclodextrin can stabilize the low-valent Mn^(II)-TPP.In vitro cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells.In vitro MR imaging experiment indicates a slightly increased T_(1) relaxivity for this HSP compared to that for the linear supramolecular polymer.

关 键 词：hyperbranched supramolecular polymer host-guest system CYCLODEXTRIN Mn-porphyrin MRI 

分 类 号：O62[理学—有机化学]